Abstract
Repeated amphetamine administration produced behavioral sensitization to subsequent amphetamine challenge. The development of sensitization was blocked by coadministration of the N-methyl-d-aspartate (NMDA) antagonist MK-801. Conditioned locomotion, as revealed by saline challenge, was also blocked by MK-801, suggesting that behavioral sensitization and conditioned locomotion may share a requirement for NMDA receptor stimulation. Repeated MK-801 administration produced behavioral sensitization to MK-801 but not amphetamine challenge, suggesting that MK-801 itself produces sensitization through a different mechanism than amphetamine.
Original language | English (US) |
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Pages (from-to) | 164-168 |
Number of pages | 5 |
Journal | Brain research |
Volume | 562 |
Issue number | 1 |
DOIs | |
State | Published - Oct 18 1991 |
Externally published | Yes |
Keywords
- Amphetamine
- Glutamate
- Locomotion
- MK-801
- N-Methyl-d-aspartate
- Sensitization
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology