Renal Infectious Diseases

Mazdak Khalighi, A. Chang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Infectious diseases are a major cause of morbidity and mortaLity in humans throughout the world. Renal involvement by a variety of infectious etiologies either in isolation or during widespread dissemination can result in significant organ dysfunction. Viruses, such as human polyomavirus or adenovirus, can directly infect kidney tubular epitheLial cells and induce tubulointerstitial inflammatory responses. Alternatively, the immune response of the host to offending viruses, such as hepatitis B, hepatitis C virus, or human immunodeficiency virus, can lead to immune complex formation resulting in a variety of glomerular patterns of injury. Fungal and mycobacterial infections injure primarily through direct colonization of the kidney, which may be exacerbated by the associated inflammatory response to the initial infection. The kidney has a Limited number of ways to respond to the wide array of infectious agents. Therefore, there are many overlapping histopathologic features, and definitive identification of the offending microorganism based on a kidney biopsy can be a diagnostic challenge. The wide spectrum of renal diseases in humans caused by common viral, fungal, and mycobacterial pathogens will be reviewed. Bacterial infections involving the kidney will be discussed elsewhere.

Original languageEnglish (US)
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Pages2857-2868
Number of pages12
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Adenovirus
  • Aspergillosis
  • Blastomycosis
  • Candidiasis
  • Cryptococcosis
  • Cytomegalovirus
  • Hepatitis B virus
  • Hepatitis C virus
  • Histoplasmosis
  • Human immunodeficiency virus
  • Mucormycosis
  • Mycobacteria
  • Polyomavirus

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Khalighi, M., & Chang, A. (2014). Renal Infectious Diseases. In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (pp. 2857-2868). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386456-7.05413-7