Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC: The PLATINO Longitudinal Study

Rogelio Perez-Padilla, Fernando C. Wehrmeister, Bartolome R. Celli, Maria Victorina Lopez-Varela, Maria Montes de Oca, Adriana Muiño, Carlos Talamo, Jose R. Jardim, Gonzalo Valdivia, Carmen Lisboa, Ana Maria B Menezes, A (Sonia) Buist, William Vollmer, Carlos Torres, Juan Luna, Roberto Rodriguez-Roisin, Bartolome Celli, María Márquez, María Blanco, Edilberto PachecoFernanda Rosa, Aquiles Camelier, Francisco Franco-Marina, Alexander Corcho, Dolores Moreno, Julio Pertuze

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

QUESTION:A 6-second spirometry test is easier than full exhalations. We compared the reliability of the ratio of the Forced expiratory volume in 1 second/Forced expiratory volume in 6 seconds (FEV1/FEV6) to the ratio of the FEV1/Forced vital capacity (FEV1/FVC) for the detection of airway obstruction.METHODS:The PLATINO population-based survey in individuals aged 40 years and over designed to estimate the prevalence of post-Bronchodilator airway obstruction repeated for the same study participants after 5-9 years in three Latin-American cities.RESULTS:Using the FEV1/FVC1/FEV6 to define airway obstruction, the changes in prevalence were smaller: 9.7 to 10.6% in Montevideo, 8.6 to 9.0% in São Paulo, and 7.5 to 7.9% in Santiago. Changes in the prevalence of COPD with criteria based on FEV1/FVC correlated strongly with changes in the FET of the tests (R2 0.92) unlike the prevalence based on a low FEV1/FEV6 (R2 = 0.40).CONCLUSION:The FEV1/FEV6 is a more reliable index than FEV1/FVC because FVC varies with the duration of the forced exhalation. Reporting FET and FEV1/FEV61/FVC-derived indices.

Original languageEnglish (US)
Article numbere67960
JournalPLoS One
Volume8
Issue number8
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

Fingerprint

Vital Capacity
Forced Expiratory Volume
longitudinal studies
air flow
Longitudinal Studies
Field effect transistors
Airway Obstruction
Exhalation
Bronchodilator Agents
breathing
bronchodilators
Spirometry
Chronic Obstructive Pulmonary Disease
testing
duration
Population

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Perez-Padilla, R., Wehrmeister, F. C., Celli, B. R., Lopez-Varela, M. V., Montes de Oca, M., Muiño, A., ... Pertuze, J. (2013). Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC: The PLATINO Longitudinal Study. PLoS One, 8(8), [e67960]. https://doi.org/10.1371/journal.pone.0067960

Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC : The PLATINO Longitudinal Study. / Perez-Padilla, Rogelio; Wehrmeister, Fernando C.; Celli, Bartolome R.; Lopez-Varela, Maria Victorina; Montes de Oca, Maria; Muiño, Adriana; Talamo, Carlos; Jardim, Jose R.; Valdivia, Gonzalo; Lisboa, Carmen; Menezes, Ana Maria B; Buist, A (Sonia); Vollmer, William; Torres, Carlos; Luna, Juan; Rodriguez-Roisin, Roberto; Celli, Bartolome; Márquez, María; Blanco, María; Pacheco, Edilberto; Rosa, Fernanda; Camelier, Aquiles; Franco-Marina, Francisco; Corcho, Alexander; Moreno, Dolores; Pertuze, Julio.

In: PLoS One, Vol. 8, No. 8, e67960, 01.08.2013.

Research output: Contribution to journalArticle

Perez-Padilla, R, Wehrmeister, FC, Celli, BR, Lopez-Varela, MV, Montes de Oca, M, Muiño, A, Talamo, C, Jardim, JR, Valdivia, G, Lisboa, C, Menezes, AMB, Buist, AS, Vollmer, W, Torres, C, Luna, J, Rodriguez-Roisin, R, Celli, B, Márquez, M, Blanco, M, Pacheco, E, Rosa, F, Camelier, A, Franco-Marina, F, Corcho, A, Moreno, D & Pertuze, J 2013, 'Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC: The PLATINO Longitudinal Study', PLoS One, vol. 8, no. 8, e67960. https://doi.org/10.1371/journal.pone.0067960
Perez-Padilla R, Wehrmeister FC, Celli BR, Lopez-Varela MV, Montes de Oca M, Muiño A et al. Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC: The PLATINO Longitudinal Study. PLoS One. 2013 Aug 1;8(8). e67960. https://doi.org/10.1371/journal.pone.0067960
Perez-Padilla, Rogelio ; Wehrmeister, Fernando C. ; Celli, Bartolome R. ; Lopez-Varela, Maria Victorina ; Montes de Oca, Maria ; Muiño, Adriana ; Talamo, Carlos ; Jardim, Jose R. ; Valdivia, Gonzalo ; Lisboa, Carmen ; Menezes, Ana Maria B ; Buist, A (Sonia) ; Vollmer, William ; Torres, Carlos ; Luna, Juan ; Rodriguez-Roisin, Roberto ; Celli, Bartolome ; Márquez, María ; Blanco, María ; Pacheco, Edilberto ; Rosa, Fernanda ; Camelier, Aquiles ; Franco-Marina, Francisco ; Corcho, Alexander ; Moreno, Dolores ; Pertuze, Julio. / Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC : The PLATINO Longitudinal Study. In: PLoS One. 2013 ; Vol. 8, No. 8.
@article{2eb55c4949ad455a99de4c1052c79696,
title = "Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC: The PLATINO Longitudinal Study",
abstract = "QUESTION:A 6-second spirometry test is easier than full exhalations. We compared the reliability of the ratio of the Forced expiratory volume in 1 second/Forced expiratory volume in 6 seconds (FEV1/FEV6) to the ratio of the FEV1/Forced vital capacity (FEV1/FVC) for the detection of airway obstruction.METHODS:The PLATINO population-based survey in individuals aged 40 years and over designed to estimate the prevalence of post-Bronchodilator airway obstruction repeated for the same study participants after 5-9 years in three Latin-American cities.RESULTS:Using the FEV1/FVC1/FEV6 to define airway obstruction, the changes in prevalence were smaller: 9.7 to 10.6{\%} in Montevideo, 8.6 to 9.0{\%} in S{\~a}o Paulo, and 7.5 to 7.9{\%} in Santiago. Changes in the prevalence of COPD with criteria based on FEV1/FVC correlated strongly with changes in the FET of the tests (R2 0.92) unlike the prevalence based on a low FEV1/FEV6 (R2 = 0.40).CONCLUSION:The FEV1/FEV6 is a more reliable index than FEV1/FVC because FVC varies with the duration of the forced exhalation. Reporting FET and FEV1/FEV61/FVC-derived indices.",
author = "Rogelio Perez-Padilla and Wehrmeister, {Fernando C.} and Celli, {Bartolome R.} and Lopez-Varela, {Maria Victorina} and {Montes de Oca}, Maria and Adriana Mui{\~n}o and Carlos Talamo and Jardim, {Jose R.} and Gonzalo Valdivia and Carmen Lisboa and Menezes, {Ana Maria B} and Buist, {A (Sonia)} and William Vollmer and Carlos Torres and Juan Luna and Roberto Rodriguez-Roisin and Bartolome Celli and Mar{\'i}a M{\'a}rquez and Mar{\'i}a Blanco and Edilberto Pacheco and Fernanda Rosa and Aquiles Camelier and Francisco Franco-Marina and Alexander Corcho and Dolores Moreno and Julio Pertuze",
year = "2013",
month = "8",
day = "1",
doi = "10.1371/journal.pone.0067960",
language = "English (US)",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

TY - JOUR

T1 - Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC

T2 - The PLATINO Longitudinal Study

AU - Perez-Padilla, Rogelio

AU - Wehrmeister, Fernando C.

AU - Celli, Bartolome R.

AU - Lopez-Varela, Maria Victorina

AU - Montes de Oca, Maria

AU - Muiño, Adriana

AU - Talamo, Carlos

AU - Jardim, Jose R.

AU - Valdivia, Gonzalo

AU - Lisboa, Carmen

AU - Menezes, Ana Maria B

AU - Buist, A (Sonia)

AU - Vollmer, William

AU - Torres, Carlos

AU - Luna, Juan

AU - Rodriguez-Roisin, Roberto

AU - Celli, Bartolome

AU - Márquez, María

AU - Blanco, María

AU - Pacheco, Edilberto

AU - Rosa, Fernanda

AU - Camelier, Aquiles

AU - Franco-Marina, Francisco

AU - Corcho, Alexander

AU - Moreno, Dolores

AU - Pertuze, Julio

PY - 2013/8/1

Y1 - 2013/8/1

N2 - QUESTION:A 6-second spirometry test is easier than full exhalations. We compared the reliability of the ratio of the Forced expiratory volume in 1 second/Forced expiratory volume in 6 seconds (FEV1/FEV6) to the ratio of the FEV1/Forced vital capacity (FEV1/FVC) for the detection of airway obstruction.METHODS:The PLATINO population-based survey in individuals aged 40 years and over designed to estimate the prevalence of post-Bronchodilator airway obstruction repeated for the same study participants after 5-9 years in three Latin-American cities.RESULTS:Using the FEV1/FVC1/FEV6 to define airway obstruction, the changes in prevalence were smaller: 9.7 to 10.6% in Montevideo, 8.6 to 9.0% in São Paulo, and 7.5 to 7.9% in Santiago. Changes in the prevalence of COPD with criteria based on FEV1/FVC correlated strongly with changes in the FET of the tests (R2 0.92) unlike the prevalence based on a low FEV1/FEV6 (R2 = 0.40).CONCLUSION:The FEV1/FEV6 is a more reliable index than FEV1/FVC because FVC varies with the duration of the forced exhalation. Reporting FET and FEV1/FEV61/FVC-derived indices.

AB - QUESTION:A 6-second spirometry test is easier than full exhalations. We compared the reliability of the ratio of the Forced expiratory volume in 1 second/Forced expiratory volume in 6 seconds (FEV1/FEV6) to the ratio of the FEV1/Forced vital capacity (FEV1/FVC) for the detection of airway obstruction.METHODS:The PLATINO population-based survey in individuals aged 40 years and over designed to estimate the prevalence of post-Bronchodilator airway obstruction repeated for the same study participants after 5-9 years in three Latin-American cities.RESULTS:Using the FEV1/FVC1/FEV6 to define airway obstruction, the changes in prevalence were smaller: 9.7 to 10.6% in Montevideo, 8.6 to 9.0% in São Paulo, and 7.5 to 7.9% in Santiago. Changes in the prevalence of COPD with criteria based on FEV1/FVC correlated strongly with changes in the FET of the tests (R2 0.92) unlike the prevalence based on a low FEV1/FEV6 (R2 = 0.40).CONCLUSION:The FEV1/FEV6 is a more reliable index than FEV1/FVC because FVC varies with the duration of the forced exhalation. Reporting FET and FEV1/FEV61/FVC-derived indices.

UR - http://www.scopus.com/inward/record.url?scp=84881002242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881002242&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0067960

DO - 10.1371/journal.pone.0067960

M3 - Article

C2 - 23936297

AN - SCOPUS:84881002242

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e67960

ER -