TY - JOUR
T1 - Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC
T2 - The PLATINO Longitudinal Study
AU - Perez-Padilla, Rogelio
AU - Wehrmeister, Fernando C.
AU - Celli, Bartolome R.
AU - Lopez-Varela, Maria Victorina
AU - Montes de Oca, Maria
AU - Muiño, Adriana
AU - Talamo, Carlos
AU - Jardim, Jose R.
AU - Valdivia, Gonzalo
AU - Lisboa, Carmen
AU - Menezes, Ana Maria B.
AU - Buist, Sonia
AU - Vollmer, William
AU - Torres, Carlos
AU - Luna, Juan
AU - Rodriguez-Roisin, Roberto
AU - Márquez, María
AU - Blanco, María
AU - Pacheco, Edilberto
AU - Rosa, Fernanda
AU - Camelier, Aquiles
AU - Franco-Marina, Francisco
AU - Corcho, Alexander
AU - Moreno, Dolores
AU - Pertuze, Julio
PY - 2013/8/1
Y1 - 2013/8/1
N2 - QUESTION:A 6-second spirometry test is easier than full exhalations. We compared the reliability of the ratio of the Forced expiratory volume in 1 second/Forced expiratory volume in 6 seconds (FEV1/FEV6) to the ratio of the FEV1/Forced vital capacity (FEV1/FVC) for the detection of airway obstruction.METHODS:The PLATINO population-based survey in individuals aged 40 years and over designed to estimate the prevalence of post-Bronchodilator airway obstruction repeated for the same study participants after 5-9 years in three Latin-American cities.RESULTS:Using the FEV1/FVC<Lower limit of normal (LLN) index, COPD prevalence apparently changed from 9.8 to 13.2% in Montevideo, from 9.7 to 6.0% in São Paulo and from 8.5 to 6.6% in Santiago, despite only slight declines in smoking prevalence (from 30.8% to 24.3%). These changes were associated with differences in Forced expiratory time (FET) between the two surveys. In contrast, by using the FEV1/FEV6 to define airway obstruction, the changes in prevalence were smaller: 9.7 to 10.6% in Montevideo, 8.6 to 9.0% in São Paulo, and 7.5 to 7.9% in Santiago. Changes in the prevalence of COPD with criteria based on FEV1/FVC correlated strongly with changes in the FET of the tests (R2 0.92) unlike the prevalence based on a low FEV1/FEV6 (R2 = 0.40).CONCLUSION:The FEV1/FEV6 is a more reliable index than FEV1/FVC because FVC varies with the duration of the forced exhalation. Reporting FET and FEV1/FEV6<LLN helps to understand differences in prevalence of COPD obtained from FEV1/FVC-derived indices.
AB - QUESTION:A 6-second spirometry test is easier than full exhalations. We compared the reliability of the ratio of the Forced expiratory volume in 1 second/Forced expiratory volume in 6 seconds (FEV1/FEV6) to the ratio of the FEV1/Forced vital capacity (FEV1/FVC) for the detection of airway obstruction.METHODS:The PLATINO population-based survey in individuals aged 40 years and over designed to estimate the prevalence of post-Bronchodilator airway obstruction repeated for the same study participants after 5-9 years in three Latin-American cities.RESULTS:Using the FEV1/FVC<Lower limit of normal (LLN) index, COPD prevalence apparently changed from 9.8 to 13.2% in Montevideo, from 9.7 to 6.0% in São Paulo and from 8.5 to 6.6% in Santiago, despite only slight declines in smoking prevalence (from 30.8% to 24.3%). These changes were associated with differences in Forced expiratory time (FET) between the two surveys. In contrast, by using the FEV1/FEV6 to define airway obstruction, the changes in prevalence were smaller: 9.7 to 10.6% in Montevideo, 8.6 to 9.0% in São Paulo, and 7.5 to 7.9% in Santiago. Changes in the prevalence of COPD with criteria based on FEV1/FVC correlated strongly with changes in the FET of the tests (R2 0.92) unlike the prevalence based on a low FEV1/FEV6 (R2 = 0.40).CONCLUSION:The FEV1/FEV6 is a more reliable index than FEV1/FVC because FVC varies with the duration of the forced exhalation. Reporting FET and FEV1/FEV6<LLN helps to understand differences in prevalence of COPD obtained from FEV1/FVC-derived indices.
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U2 - 10.1371/journal.pone.0067960
DO - 10.1371/journal.pone.0067960
M3 - Article
C2 - 23936297
AN - SCOPUS:84881002242
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 8
M1 - e67960
ER -