Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC: The PLATINO Longitudinal Study

Rogelio Perez-Padilla, Fernando C. Wehrmeister, Bartolome R. Celli, Maria Victorina Lopez-Varela, Maria Montes de Oca, Adriana Muiño, Carlos Talamo, Jose R. Jardim, Gonzalo Valdivia, Carmen Lisboa, Ana Maria B. Menezes, Sonia Buist, William Vollmer, Carlos Torres, Juan Luna, Roberto Rodriguez-Roisin, Bartolome Celli, María Márquez, María Blanco, Edilberto PachecoFernanda Rosa, Aquiles Camelier, Francisco Franco-Marina, Alexander Corcho, Dolores Moreno, Julio Pertuze

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22 Scopus citations

Abstract

QUESTION:A 6-second spirometry test is easier than full exhalations. We compared the reliability of the ratio of the Forced expiratory volume in 1 second/Forced expiratory volume in 6 seconds (FEV1/FEV6) to the ratio of the FEV1/Forced vital capacity (FEV1/FVC) for the detection of airway obstruction.METHODS:The PLATINO population-based survey in individuals aged 40 years and over designed to estimate the prevalence of post-Bronchodilator airway obstruction repeated for the same study participants after 5-9 years in three Latin-American cities.RESULTS:Using the FEV1/FVC<Lower limit of normal (LLN) index, COPD prevalence apparently changed from 9.8 to 13.2% in Montevideo, from 9.7 to 6.0% in São Paulo and from 8.5 to 6.6% in Santiago, despite only slight declines in smoking prevalence (from 30.8% to 24.3%). These changes were associated with differences in Forced expiratory time (FET) between the two surveys. In contrast, by using the FEV1/FEV6 to define airway obstruction, the changes in prevalence were smaller: 9.7 to 10.6% in Montevideo, 8.6 to 9.0% in São Paulo, and 7.5 to 7.9% in Santiago. Changes in the prevalence of COPD with criteria based on FEV1/FVC correlated strongly with changes in the FET of the tests (R2 0.92) unlike the prevalence based on a low FEV1/FEV6 (R2 = 0.40).CONCLUSION:The FEV1/FEV6 is a more reliable index than FEV1/FVC because FVC varies with the duration of the forced exhalation. Reporting FET and FEV1/FEV6<LLN helps to understand differences in prevalence of COPD obtained from FEV1/FVC-derived indices.

Original languageEnglish (US)
Article numbere67960
JournalPloS one
Volume8
Issue number8
DOIs
StatePublished - Aug 1 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Perez-Padilla, R., Wehrmeister, F. C., Celli, B. R., Lopez-Varela, M. V., Montes de Oca, M., Muiño, A., Talamo, C., Jardim, J. R., Valdivia, G., Lisboa, C., Menezes, A. M. B., Buist, S., Vollmer, W., Torres, C., Luna, J., Rodriguez-Roisin, R., Celli, B., Márquez, M., Blanco, M., ... Pertuze, J. (2013). Reliability of FEV1/FEV6 to Diagnose Airflow Obstruction Compared with FEV1/FVC: The PLATINO Longitudinal Study. PloS one, 8(8), [e67960]. https://doi.org/10.1371/journal.pone.0067960