Relative Survival Rates after Alternative Therapies for Uveal Melanoma

Johanna M. Seddon, Evangelos S. Gragoudas, Kathleen M. Egan, Robert J. Glynn, Suzanne Howard, Robert G. Fante, Daniel Albert

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Survival in a group of 556 patients with uveal melanoma treated by proton beam irradiation with a median follow-up of 5.3 years was compared with that of 238 patients enucleated during the same 10-year period as irradiated patients (July 1975 to December 1984) with a median follow-up of 8.8 years, and 257 patients enucleated during the preceding 10 years (January 1965 to June 1975) with a median follow-up of 17.0 years. Adjustments were made for known prognostic factors including age, tumor location, tumor height, and clinical estimate of tumor diameter (for enucleated patients this was estimated in a regression equation relating histologic to clinical measurement). The overall rate ratio for all cause mortality was 1.2 (95% confidence interval, 0.9-1.6) for the concurrent enucleation series versus proton beam, and 1.6 (95% confidence interval, 1.2-2.1) for the earlier enucleation series versus proton beam. Relative rates of metastatic death, cancer death, and all cause mortality comparing alternative treatments were found to vary with time after treatment. Intervalspecific rate ratios were evaluated using proportional hazards models fitted to separate time intervals after treatment. For all three outcomes, rate ratios were over two and statistically significant for the first 2 years after treatment and closer to one and nonsignificant after year 6 comparing the two enucleation groups with proton beam. Results suggest that treatment choice has little overall influence on survival in patients with uveal melanoma.

Original languageEnglish (US)
Pages (from-to)769-777
Number of pages9
JournalOphthalmology
Volume97
Issue number6
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Complementary Therapies
Survival Rate
Protons
Mortality
Neoplasms
Confidence Intervals
Therapeutics
Survival
Proportional Hazards Models
Uveal melanoma
Cause of Death

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Seddon, J. M., Gragoudas, E. S., Egan, K. M., Glynn, R. J., Howard, S., Fante, R. G., & Albert, D. (1990). Relative Survival Rates after Alternative Therapies for Uveal Melanoma. Ophthalmology, 97(6), 769-777. https://doi.org/10.1016/S0161-6420(90)32512-5

Relative Survival Rates after Alternative Therapies for Uveal Melanoma. / Seddon, Johanna M.; Gragoudas, Evangelos S.; Egan, Kathleen M.; Glynn, Robert J.; Howard, Suzanne; Fante, Robert G.; Albert, Daniel.

In: Ophthalmology, Vol. 97, No. 6, 01.01.1990, p. 769-777.

Research output: Contribution to journalArticle

Seddon, JM, Gragoudas, ES, Egan, KM, Glynn, RJ, Howard, S, Fante, RG & Albert, D 1990, 'Relative Survival Rates after Alternative Therapies for Uveal Melanoma', Ophthalmology, vol. 97, no. 6, pp. 769-777. https://doi.org/10.1016/S0161-6420(90)32512-5
Seddon JM, Gragoudas ES, Egan KM, Glynn RJ, Howard S, Fante RG et al. Relative Survival Rates after Alternative Therapies for Uveal Melanoma. Ophthalmology. 1990 Jan 1;97(6):769-777. https://doi.org/10.1016/S0161-6420(90)32512-5
Seddon, Johanna M. ; Gragoudas, Evangelos S. ; Egan, Kathleen M. ; Glynn, Robert J. ; Howard, Suzanne ; Fante, Robert G. ; Albert, Daniel. / Relative Survival Rates after Alternative Therapies for Uveal Melanoma. In: Ophthalmology. 1990 ; Vol. 97, No. 6. pp. 769-777.
@article{8b3cba44fa75439584191ce2a3b70517,
title = "Relative Survival Rates after Alternative Therapies for Uveal Melanoma",
abstract = "Survival in a group of 556 patients with uveal melanoma treated by proton beam irradiation with a median follow-up of 5.3 years was compared with that of 238 patients enucleated during the same 10-year period as irradiated patients (July 1975 to December 1984) with a median follow-up of 8.8 years, and 257 patients enucleated during the preceding 10 years (January 1965 to June 1975) with a median follow-up of 17.0 years. Adjustments were made for known prognostic factors including age, tumor location, tumor height, and clinical estimate of tumor diameter (for enucleated patients this was estimated in a regression equation relating histologic to clinical measurement). The overall rate ratio for all cause mortality was 1.2 (95{\%} confidence interval, 0.9-1.6) for the concurrent enucleation series versus proton beam, and 1.6 (95{\%} confidence interval, 1.2-2.1) for the earlier enucleation series versus proton beam. Relative rates of metastatic death, cancer death, and all cause mortality comparing alternative treatments were found to vary with time after treatment. Intervalspecific rate ratios were evaluated using proportional hazards models fitted to separate time intervals after treatment. For all three outcomes, rate ratios were over two and statistically significant for the first 2 years after treatment and closer to one and nonsignificant after year 6 comparing the two enucleation groups with proton beam. Results suggest that treatment choice has little overall influence on survival in patients with uveal melanoma.",
author = "Seddon, {Johanna M.} and Gragoudas, {Evangelos S.} and Egan, {Kathleen M.} and Glynn, {Robert J.} and Suzanne Howard and Fante, {Robert G.} and Daniel Albert",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/S0161-6420(90)32512-5",
language = "English (US)",
volume = "97",
pages = "769--777",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Relative Survival Rates after Alternative Therapies for Uveal Melanoma

AU - Seddon, Johanna M.

AU - Gragoudas, Evangelos S.

AU - Egan, Kathleen M.

AU - Glynn, Robert J.

AU - Howard, Suzanne

AU - Fante, Robert G.

AU - Albert, Daniel

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Survival in a group of 556 patients with uveal melanoma treated by proton beam irradiation with a median follow-up of 5.3 years was compared with that of 238 patients enucleated during the same 10-year period as irradiated patients (July 1975 to December 1984) with a median follow-up of 8.8 years, and 257 patients enucleated during the preceding 10 years (January 1965 to June 1975) with a median follow-up of 17.0 years. Adjustments were made for known prognostic factors including age, tumor location, tumor height, and clinical estimate of tumor diameter (for enucleated patients this was estimated in a regression equation relating histologic to clinical measurement). The overall rate ratio for all cause mortality was 1.2 (95% confidence interval, 0.9-1.6) for the concurrent enucleation series versus proton beam, and 1.6 (95% confidence interval, 1.2-2.1) for the earlier enucleation series versus proton beam. Relative rates of metastatic death, cancer death, and all cause mortality comparing alternative treatments were found to vary with time after treatment. Intervalspecific rate ratios were evaluated using proportional hazards models fitted to separate time intervals after treatment. For all three outcomes, rate ratios were over two and statistically significant for the first 2 years after treatment and closer to one and nonsignificant after year 6 comparing the two enucleation groups with proton beam. Results suggest that treatment choice has little overall influence on survival in patients with uveal melanoma.

AB - Survival in a group of 556 patients with uveal melanoma treated by proton beam irradiation with a median follow-up of 5.3 years was compared with that of 238 patients enucleated during the same 10-year period as irradiated patients (July 1975 to December 1984) with a median follow-up of 8.8 years, and 257 patients enucleated during the preceding 10 years (January 1965 to June 1975) with a median follow-up of 17.0 years. Adjustments were made for known prognostic factors including age, tumor location, tumor height, and clinical estimate of tumor diameter (for enucleated patients this was estimated in a regression equation relating histologic to clinical measurement). The overall rate ratio for all cause mortality was 1.2 (95% confidence interval, 0.9-1.6) for the concurrent enucleation series versus proton beam, and 1.6 (95% confidence interval, 1.2-2.1) for the earlier enucleation series versus proton beam. Relative rates of metastatic death, cancer death, and all cause mortality comparing alternative treatments were found to vary with time after treatment. Intervalspecific rate ratios were evaluated using proportional hazards models fitted to separate time intervals after treatment. For all three outcomes, rate ratios were over two and statistically significant for the first 2 years after treatment and closer to one and nonsignificant after year 6 comparing the two enucleation groups with proton beam. Results suggest that treatment choice has little overall influence on survival in patients with uveal melanoma.

UR - http://www.scopus.com/inward/record.url?scp=0025314508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025314508&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(90)32512-5

DO - 10.1016/S0161-6420(90)32512-5

M3 - Article

C2 - 2374681

AN - SCOPUS:0025314508

VL - 97

SP - 769

EP - 777

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 6

ER -