TY - JOUR
T1 - Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos
T2 - the Center for Alaska Native Health Research study
AU - Goropashnaya, Anna V.
AU - Herron, Johanna
AU - Sexton, Mary
AU - Havel, Peter J.
AU - Stanhope, Kimber L.
AU - Plaetke, Rosemarie
AU - Mohatt, Gerald V.
AU - Boyer, Bert B.
N1 - Funding Information:
The CANHR study is funded by a grant from the National Center for Research Resources at the National Institutes of Health (NIH) (P20 RR16430, to Dr Gerald Mohatt). Dr Havel's research program receives support from NIH grants HL-091333, HL-075675, AT-002599, AT-002993, and AT-003645 and the American Diabetes Association. Dr Boyer's research program is supported by NIH grant DK 074842. The authors thank Dr. William Knowler and 2 anonymous reviewers for valuable comments. We also thank the community field research assistants and the computer/data management and administrative staff members: Michelle Dondanville, Jean James, Yongmei Qin, Judy Romans, and Yichen Wang. Finally, we are grateful to the members and leaders of Yup'ik communities of the Yukon-Kuskokwim Delta region in Southwest Alaska for their cooperation during our study.
PY - 2009/1
Y1 - 2009/1
N2 - Adiponectin, a protein secreted by adipose tissue, has antiatherogenic, anti-inflammatory, and insulin-sensitizing actions. We examined the relationship between plasma adiponectin and adiposity, insulin resistance, plasma lipids, glucose, leptin, and anthropometric measurements in 316 adult men and 353 adult women Yup'ik Eskimos in Southwest Alaska. Adiponectin concentration was negatively associated with body mass index, percentage of body fat, sum of skin folds, waist circumference, triglycerides, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), fasting insulin, and leptin in both men and women, and also with glucose in women. Adiponectin concentration correlated positively with high-density lipoprotein cholesterol concentration, and also with low-density lipoprotein cholesterol in women. Insulin-sensitive individuals (HOMA-IR <3.52, n = 442) had higher plasma adiponectin concentrations than more insulin-resistant individuals (HOMA-IR ≥3.52, n = 224): 11.02 ± 0.27 μg/mL vs 8.26 ± 0.32 μg/mL, P < .001. Adiponectin concentrations did not differ between groups of participants with low and high level of risk for developing coronary heart disease. No difference in plasma adiponectin levels was found among Yup'ik Eskimos and whites matched for sex, age, and body mass index. In conclusion, circulating adiponectin concentrations were most strongly associated with sum of skin folds in Yup'ik men and with high-density lipoprotein cholesterol levels, sum of skin folds, waist circumference, and insulin and triglycerides concentrations in Yup'ik women.
AB - Adiponectin, a protein secreted by adipose tissue, has antiatherogenic, anti-inflammatory, and insulin-sensitizing actions. We examined the relationship between plasma adiponectin and adiposity, insulin resistance, plasma lipids, glucose, leptin, and anthropometric measurements in 316 adult men and 353 adult women Yup'ik Eskimos in Southwest Alaska. Adiponectin concentration was negatively associated with body mass index, percentage of body fat, sum of skin folds, waist circumference, triglycerides, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), fasting insulin, and leptin in both men and women, and also with glucose in women. Adiponectin concentration correlated positively with high-density lipoprotein cholesterol concentration, and also with low-density lipoprotein cholesterol in women. Insulin-sensitive individuals (HOMA-IR <3.52, n = 442) had higher plasma adiponectin concentrations than more insulin-resistant individuals (HOMA-IR ≥3.52, n = 224): 11.02 ± 0.27 μg/mL vs 8.26 ± 0.32 μg/mL, P < .001. Adiponectin concentrations did not differ between groups of participants with low and high level of risk for developing coronary heart disease. No difference in plasma adiponectin levels was found among Yup'ik Eskimos and whites matched for sex, age, and body mass index. In conclusion, circulating adiponectin concentrations were most strongly associated with sum of skin folds in Yup'ik men and with high-density lipoprotein cholesterol levels, sum of skin folds, waist circumference, and insulin and triglycerides concentrations in Yup'ik women.
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U2 - 10.1016/j.metabol.2008.09.002
DO - 10.1016/j.metabol.2008.09.002
M3 - Article
C2 - 19059527
AN - SCOPUS:57049139958
SN - 0026-0495
VL - 58
SP - 22
EP - 29
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 1
ER -