Relationship between dual-energy X-ray absorptiometry volumetric assessment and X-ray computed tomography-derived single-slice measurement of visceral fat

Yi Xia, David L. Ergun, Wynn K. Wacker, Xin Wang, Cynthia E. Davis, Sanjiv Kaul

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    To reduce radiation exposure and cost, visceral adipose tissue (VAT) measurement on X-ray computed tomography (CT) has been limited to a single slice. Recently, the US Food and Drug Administration has approved a dual-energy X-ray absorptiometry (DXA) application validated against CT to measure VAT volume. The purpose of this study was to develop an algorithm to compute single-slice area values on DXA at 2 common landmarks, L2/3 and L4/5, from an automated volumetrically derived measurement of VAT. Volumetric CT and total body DXA were measured in 55 males (age: 21-77 yr; body mass index [BMI]: 21.1-37.9) and 60 females (age: 21-85 yr; BMI: 20.0-39.7). Equations were developed by applying the relationship of CT single-slice area and volume measurements of VAT to the DXA VAT volume measure as well as validating these against the CT single-slice measurements. Correlation coefficients between DXA estimate of single-slice area and CT were 0.94 for L2/3 and 0.96 for L4/5. The mean difference between DXA estimate of single-slice area and CT was 5 cm2 at L2/3 and 3.8 cm2 at L4/5. Bland-Altman analysis showed a fairly constant difference across the single-slice range inthisstudy, and the 95% limits of agreement for the 2 methods were -44.6 to +54.6 cm2 for L2/3 and -47.3 to+54.9 cm2 for L4/5. In conclusion, a volumetric measurement of VAT by DXA can be used to estimate single-slice measurements at the L2/3 and the L4/5 landmarks.

    Original languageEnglish (US)
    Pages (from-to)78-83
    Number of pages6
    JournalJournal of Clinical Densitometry
    Volume17
    Issue number1
    DOIs
    StatePublished - Jan 2014

    Fingerprint

    X Ray Computed Tomography
    Intra-Abdominal Fat
    Photon Absorptiometry
    Tomography
    Body Mass Index
    Cone-Beam Computed Tomography
    United States Food and Drug Administration
    Costs and Cost Analysis

    Keywords

    • Dual-energy X-ray absorptiometry
    • Visceral fat
    • X-ray computed tomography

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Orthopedics and Sports Medicine
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Relationship between dual-energy X-ray absorptiometry volumetric assessment and X-ray computed tomography-derived single-slice measurement of visceral fat. / Xia, Yi; Ergun, David L.; Wacker, Wynn K.; Wang, Xin; Davis, Cynthia E.; Kaul, Sanjiv.

    In: Journal of Clinical Densitometry, Vol. 17, No. 1, 01.2014, p. 78-83.

    Research output: Contribution to journalArticle

    @article{6d348fef857f4a9dbb8f031b5020f0dd,
    title = "Relationship between dual-energy X-ray absorptiometry volumetric assessment and X-ray computed tomography-derived single-slice measurement of visceral fat",
    abstract = "To reduce radiation exposure and cost, visceral adipose tissue (VAT) measurement on X-ray computed tomography (CT) has been limited to a single slice. Recently, the US Food and Drug Administration has approved a dual-energy X-ray absorptiometry (DXA) application validated against CT to measure VAT volume. The purpose of this study was to develop an algorithm to compute single-slice area values on DXA at 2 common landmarks, L2/3 and L4/5, from an automated volumetrically derived measurement of VAT. Volumetric CT and total body DXA were measured in 55 males (age: 21-77 yr; body mass index [BMI]: 21.1-37.9) and 60 females (age: 21-85 yr; BMI: 20.0-39.7). Equations were developed by applying the relationship of CT single-slice area and volume measurements of VAT to the DXA VAT volume measure as well as validating these against the CT single-slice measurements. Correlation coefficients between DXA estimate of single-slice area and CT were 0.94 for L2/3 and 0.96 for L4/5. The mean difference between DXA estimate of single-slice area and CT was 5 cm2 at L2/3 and 3.8 cm2 at L4/5. Bland-Altman analysis showed a fairly constant difference across the single-slice range inthisstudy, and the 95{\%} limits of agreement for the 2 methods were -44.6 to +54.6 cm2 for L2/3 and -47.3 to+54.9 cm2 for L4/5. In conclusion, a volumetric measurement of VAT by DXA can be used to estimate single-slice measurements at the L2/3 and the L4/5 landmarks.",
    keywords = "Dual-energy X-ray absorptiometry, Visceral fat, X-ray computed tomography",
    author = "Yi Xia and Ergun, {David L.} and Wacker, {Wynn K.} and Xin Wang and Davis, {Cynthia E.} and Sanjiv Kaul",
    year = "2014",
    month = "1",
    doi = "10.1016/j.jocd.2013.03.007",
    language = "English (US)",
    volume = "17",
    pages = "78--83",
    journal = "Journal of Clinical Densitometry",
    issn = "1094-6950",
    publisher = "Elsevier Inc.",
    number = "1",

    }

    TY - JOUR

    T1 - Relationship between dual-energy X-ray absorptiometry volumetric assessment and X-ray computed tomography-derived single-slice measurement of visceral fat

    AU - Xia, Yi

    AU - Ergun, David L.

    AU - Wacker, Wynn K.

    AU - Wang, Xin

    AU - Davis, Cynthia E.

    AU - Kaul, Sanjiv

    PY - 2014/1

    Y1 - 2014/1

    N2 - To reduce radiation exposure and cost, visceral adipose tissue (VAT) measurement on X-ray computed tomography (CT) has been limited to a single slice. Recently, the US Food and Drug Administration has approved a dual-energy X-ray absorptiometry (DXA) application validated against CT to measure VAT volume. The purpose of this study was to develop an algorithm to compute single-slice area values on DXA at 2 common landmarks, L2/3 and L4/5, from an automated volumetrically derived measurement of VAT. Volumetric CT and total body DXA were measured in 55 males (age: 21-77 yr; body mass index [BMI]: 21.1-37.9) and 60 females (age: 21-85 yr; BMI: 20.0-39.7). Equations were developed by applying the relationship of CT single-slice area and volume measurements of VAT to the DXA VAT volume measure as well as validating these against the CT single-slice measurements. Correlation coefficients between DXA estimate of single-slice area and CT were 0.94 for L2/3 and 0.96 for L4/5. The mean difference between DXA estimate of single-slice area and CT was 5 cm2 at L2/3 and 3.8 cm2 at L4/5. Bland-Altman analysis showed a fairly constant difference across the single-slice range inthisstudy, and the 95% limits of agreement for the 2 methods were -44.6 to +54.6 cm2 for L2/3 and -47.3 to+54.9 cm2 for L4/5. In conclusion, a volumetric measurement of VAT by DXA can be used to estimate single-slice measurements at the L2/3 and the L4/5 landmarks.

    AB - To reduce radiation exposure and cost, visceral adipose tissue (VAT) measurement on X-ray computed tomography (CT) has been limited to a single slice. Recently, the US Food and Drug Administration has approved a dual-energy X-ray absorptiometry (DXA) application validated against CT to measure VAT volume. The purpose of this study was to develop an algorithm to compute single-slice area values on DXA at 2 common landmarks, L2/3 and L4/5, from an automated volumetrically derived measurement of VAT. Volumetric CT and total body DXA were measured in 55 males (age: 21-77 yr; body mass index [BMI]: 21.1-37.9) and 60 females (age: 21-85 yr; BMI: 20.0-39.7). Equations were developed by applying the relationship of CT single-slice area and volume measurements of VAT to the DXA VAT volume measure as well as validating these against the CT single-slice measurements. Correlation coefficients between DXA estimate of single-slice area and CT were 0.94 for L2/3 and 0.96 for L4/5. The mean difference between DXA estimate of single-slice area and CT was 5 cm2 at L2/3 and 3.8 cm2 at L4/5. Bland-Altman analysis showed a fairly constant difference across the single-slice range inthisstudy, and the 95% limits of agreement for the 2 methods were -44.6 to +54.6 cm2 for L2/3 and -47.3 to+54.9 cm2 for L4/5. In conclusion, a volumetric measurement of VAT by DXA can be used to estimate single-slice measurements at the L2/3 and the L4/5 landmarks.

    KW - Dual-energy X-ray absorptiometry

    KW - Visceral fat

    KW - X-ray computed tomography

    UR - http://www.scopus.com/inward/record.url?scp=84895009273&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84895009273&partnerID=8YFLogxK

    U2 - 10.1016/j.jocd.2013.03.007

    DO - 10.1016/j.jocd.2013.03.007

    M3 - Article

    VL - 17

    SP - 78

    EP - 83

    JO - Journal of Clinical Densitometry

    JF - Journal of Clinical Densitometry

    SN - 1094-6950

    IS - 1

    ER -