TY - JOUR
T1 - Relation of sleep-disordered breathing to cardiovascular disease risk factors
T2 - The Sleep Heart Health Study
AU - Newman, Anne B.
AU - Nieto, F. Javier
AU - Guidry, Ursula
AU - Lind, Bonnie K.
AU - Redline, Susan
AU - Shahar, Eyal
AU - Pickering, Thomas G.
AU - Quan, Stuart F.
N1 - Funding Information:
Supported by the National Heart, Lung, and Blood Institute through the following Cooperative Agreements: U01HL53940 (University of Washington), U01HL53941 (Boston University), U01HL53938 (University of Arizona), U01HL53916 (University of California, Davis), U01HL53934 (University of Minnesota), U01HL53931 (New York University), and U01HL53937 (Johns Hopkins University).
PY - 2001/7/1
Y1 - 2001/7/1
N2 - Associations between sleep-disordered breathing and cardiovascular disease (CVD) may be mediated by higher cardiovascular risk factor levels in those with sleep-disordered breathing. The authors examined these relations in the Sleep Heart Health Study, a multiethnic cohort of 6,440 men and women over age 40 years conducted from October 1995 to February 1998 and characterized by home polysomnography. In 4,991 participants who were free of self-reported CVD at the time of the sleep study, moderate levels of sleep-disordered breathing were common, with a median Respiratory Disturbance Index (RDI) of 4.0 (interquartile range, 1.25-10.7). The level of RDI was associated cross-sectionally with age, body mass index, waist-to-hip ratio, hypertension, diabetes, and lipid levels. These relations were more pronounced in those under age 65 years than in those over age 65. Women under age 65 years with RDI in the higher quartiles were more obese than men with similar RDI. Although the pattern of associations was consistent with greater obesity in those with higher RDI, higher body mass index did not explain all of these associations. If sleep-disordered breathing is shown in future follow-up to increase the risk for incident CVD events, part of the risk is likely to be due to the higher cardiovascular risk factors in those with higher RDI.
AB - Associations between sleep-disordered breathing and cardiovascular disease (CVD) may be mediated by higher cardiovascular risk factor levels in those with sleep-disordered breathing. The authors examined these relations in the Sleep Heart Health Study, a multiethnic cohort of 6,440 men and women over age 40 years conducted from October 1995 to February 1998 and characterized by home polysomnography. In 4,991 participants who were free of self-reported CVD at the time of the sleep study, moderate levels of sleep-disordered breathing were common, with a median Respiratory Disturbance Index (RDI) of 4.0 (interquartile range, 1.25-10.7). The level of RDI was associated cross-sectionally with age, body mass index, waist-to-hip ratio, hypertension, diabetes, and lipid levels. These relations were more pronounced in those under age 65 years than in those over age 65. Women under age 65 years with RDI in the higher quartiles were more obese than men with similar RDI. Although the pattern of associations was consistent with greater obesity in those with higher RDI, higher body mass index did not explain all of these associations. If sleep-disordered breathing is shown in future follow-up to increase the risk for incident CVD events, part of the risk is likely to be due to the higher cardiovascular risk factors in those with higher RDI.
KW - Cardiovascular diseases
KW - Respiration
KW - Sleep apnea syndromes
KW - Sleep disorders
UR - http://www.scopus.com/inward/record.url?scp=0035399626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035399626&partnerID=8YFLogxK
U2 - 10.1093/aje/154.1.50
DO - 10.1093/aje/154.1.50
M3 - Article
C2 - 11434366
AN - SCOPUS:0035399626
SN - 0002-9262
VL - 154
SP - 50
EP - 59
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 1
ER -