Relation Between Thrombolysis in Myocardial Infarction Risk Score and One-Year Outcomes for Patients Presenting at the Emergency Department With Potential Acute Coronary Syndrome

Benjamin M. Weisenthal, Anna Marie Chang, Kristy M. Walsh, Mark J. Collin, Frances S. Shofer, Judd E. Hollander

Research output: Contribution to journalArticle

14 Scopus citations


The Thrombolysis in Myocardial Infarction (TIMI) score, derived from unstable angina/non-ST-segment elevation acute myocardial infarction patient population, predicts 14-day cardiovascular events. It has been validated in emergency department (ED) patients with potential acute coronary syndrome with respect to 30-day outcomes. Our objective was to determine whether the initial TIMI score could risk stratify ED patients with potential acute coronary syndrome with respect to the 1-year outcomes. This was a prospective cohort study of patients presenting to the ED with chest pain who underwent electrocardiography. Patients with ST-segment elevation myocardial infarction (acute myocardial infarction) were excluded. Follow-up was conducted by telephone and record review >1 year after the index visit. The main outcome was the 1-year mortality, nonfatal acute myocardial infarction, or revascularization stratified by the TIMI score. Of 2,819 patients, 253 (9%) met the composite outcome. The overall incidence of the composite 1-year outcome of death (n = 119), acute myocardial infarction (n = 96), and revascularization (n = 90) according to TIMI score was TIMI 0 (n = 1,162), 4%; TIMI 1 (n = 901), 8%; TIMI 2 (n = 495), 13%; TIMI 3 (n = 193), 23%; TIMI 4 (n = 60), 28%; and TIMI 5 to 7 (n = 8), 88% (p

Original languageEnglish (US)
Pages (from-to)441-444
Number of pages4
JournalAmerican Journal of Cardiology
Issue number4
Publication statusPublished - Feb 15 2010
Externally publishedYes


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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