Reinforcing and discriminative stimulus effects of Ca-acetyl homotaurine in animals

K. A. Grant, W. L. Woolverton

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Ca-acetyl homotaurine (Ca-AOTA) has been proposed as an adjunct for ethanol detoxification. The purpose of the present experiment was to determine whether Ca-AOTA would be predicted to have abuse potential. Rhesus monkeys that were experienced in the intravenous self-administration of cocaine (n = 2) or pentobarbital (n = 2) were given the opportunity to self-administer various doses of Ca-AOTA or its vehicle (0.9% saline). Ca-AOTA (1.0-10.0 mg/kg/injection, intravenously) was not self-administered above saline levels. The discriminative stimulus effects of Ca-AOTA were evaluated in a drug discrimination procedure in which animals were trained to make one response after a training drug and a different response after saline. Rhesus monkeys trained to discriminate d-amphetaamine (n = 3) or pentobartial (n = 3) from saline were tested with doses of Ca-AOTA ranging from 10 to 100 mg/kg (PO by nasogastric tube) and at 3 different times (1,2, or 4 hr). Ca-AOTA failed to engender drug-appropriate responding at any dose or pretreatment condition in either group of monkeys. In addition, Ca-AOTA was tested in 4 pigeons trained to discriminate pentobarbital from saline. Ca-AOTA administration did not result in pentobarbital-appropriate responding in doses ranging from 30-300 mg/kg (IM) and pretreatment times ranging from 30 to 240 min. The lack of both reinforcing properties and discriminative stimulus properties to similar d-amphetamine or pentobarbital suggests that Ca-AOTA has0 little or no abuse potential.

Original languageEnglish (US)
Pages (from-to)607-611
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume32
Issue number3
DOIs
StatePublished - Mar 1989
Externally publishedYes

Keywords

  • Drug discrimination
  • Homotaurine
  • Monkeys
  • Pigeons
  • Self-administration

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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