Regulatory RNAs

J. Kreth; S. Brantl; Justin Merritt

doi:10.1016/B978-0-12-801238-3.99220-1

Regulatory RNAs

J. Kreth, S. Brantl, Justin Merritt

School of Dentistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Small RNAs gained worldwide attention in December 2002, when the journal Science published a special issue entitled “Small RNAs-Breakthrough of the Year”. However, by that time, small antisense RNAs had already been thoroughly investigated for more than 20 years for the regulation of plasmid replication/maintenance, phage replication, and transposition. Currently, it is estimated that up to 10-20% of all bacterial genes yield non-coding RNAs, many or most of which are likely to be riboregulatory. They encompass cis- and trans-encoded base pairing sRNAs, sRNAs acting via protein binding, sensory RNAs like RNA thermometers and riboswitches, as well as RNAs with other specific functions. The latter group is heterogenous and comprised of tmRNA, RNase P, 4.5S RNA, and CRISPR RNAs. The following article summarizes our current knowledge on the biochemical properties of these RNAs, their mechanisms of action, and their biological functions.

Original language	English (US)
Title of host publication	Encyclopedia of Microbiology
Publisher	Elsevier
Pages	62-84
Number of pages	23
ISBN (Electronic)	9780128117378
ISBN (Print)	9780128117361
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.99220-1
State	Published - Jan 1 2019

Keywords

4.5s rna
Antisense rna
Cis-encoded srna
Crispr
Hfq
Riboregulator
Rnase p
Small regulatory rna
Srna
Tmrna
Trans-encoded srna

ASJC Scopus subject areas

General Immunology and Microbiology

Access to Document

10.1016/B978-0-12-801238-3.99220-1

Cite this

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title = "Regulatory RNAs",

abstract = "Small RNAs gained worldwide attention in December 2002, when the journal Science published a special issue entitled “Small RNAs-Breakthrough of the Year”. However, by that time, small antisense RNAs had already been thoroughly investigated for more than 20 years for the regulation of plasmid replication/maintenance, phage replication, and transposition. Currently, it is estimated that up to 10-20% of all bacterial genes yield non-coding RNAs, many or most of which are likely to be riboregulatory. They encompass cis- and trans-encoded base pairing sRNAs, sRNAs acting via protein binding, sensory RNAs like RNA thermometers and riboswitches, as well as RNAs with other specific functions. The latter group is heterogenous and comprised of tmRNA, RNase P, 4.5S RNA, and CRISPR RNAs. The following article summarizes our current knowledge on the biochemical properties of these RNAs, their mechanisms of action, and their biological functions.",

keywords = "4.5s rna, Antisense rna, Cis-encoded srna, Crispr, Hfq, Riboregulator, Rnase p, Small regulatory rna, Srna, Tmrna, Trans-encoded srna",

author = "J. Kreth and S. Brantl and Justin Merritt",

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doi = "10.1016/B978-0-12-801238-3.99220-1",

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T1 - Regulatory RNAs

AU - Kreth, J.

AU - Brantl, S.

AU - Merritt, Justin

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Small RNAs gained worldwide attention in December 2002, when the journal Science published a special issue entitled “Small RNAs-Breakthrough of the Year”. However, by that time, small antisense RNAs had already been thoroughly investigated for more than 20 years for the regulation of plasmid replication/maintenance, phage replication, and transposition. Currently, it is estimated that up to 10-20% of all bacterial genes yield non-coding RNAs, many or most of which are likely to be riboregulatory. They encompass cis- and trans-encoded base pairing sRNAs, sRNAs acting via protein binding, sensory RNAs like RNA thermometers and riboswitches, as well as RNAs with other specific functions. The latter group is heterogenous and comprised of tmRNA, RNase P, 4.5S RNA, and CRISPR RNAs. The following article summarizes our current knowledge on the biochemical properties of these RNAs, their mechanisms of action, and their biological functions.

AB - Small RNAs gained worldwide attention in December 2002, when the journal Science published a special issue entitled “Small RNAs-Breakthrough of the Year”. However, by that time, small antisense RNAs had already been thoroughly investigated for more than 20 years for the regulation of plasmid replication/maintenance, phage replication, and transposition. Currently, it is estimated that up to 10-20% of all bacterial genes yield non-coding RNAs, many or most of which are likely to be riboregulatory. They encompass cis- and trans-encoded base pairing sRNAs, sRNAs acting via protein binding, sensory RNAs like RNA thermometers and riboswitches, as well as RNAs with other specific functions. The latter group is heterogenous and comprised of tmRNA, RNase P, 4.5S RNA, and CRISPR RNAs. The following article summarizes our current knowledge on the biochemical properties of these RNAs, their mechanisms of action, and their biological functions.

KW - 4.5s rna

KW - Antisense rna

KW - Cis-encoded srna

KW - Crispr

KW - Hfq

KW - Riboregulator

KW - Rnase p

KW - Small regulatory rna

KW - Srna

KW - Tmrna

KW - Trans-encoded srna

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DO - 10.1016/B978-0-12-801238-3.99220-1

M3 - Chapter

SN - 9780128117361

SP - 62

EP - 84

BT - Encyclopedia of Microbiology

PB - Elsevier

ER -

Regulatory RNAs

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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