Regeneration of rat optic axons into peripheral nerve grafts

M. J. Politis; P. S. Spencer

doi:10.1016/0014-4886(86)90025-7

Regeneration of rat optic axons into peripheral nerve grafts

M. J. Politis, P. S. Spencer

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The regenerative response of myelinated axons of the mammalian central nervous system was investigated by inserting peripheral nerve grafts in the vicinity of traumatized rat optic axons. Peroneal nerve grafts were inserted into crushed optic nerves and assessed for the ability to support optic axon regeneration. Regenerating axons of retinal origin were present in the peripheral nerve grafts several weeks later. Horseradish peroxidase studies indicated that retinal ganglion cells were a source for regenerating nerve fibers.

Original language	English (US)
Pages (from-to)	52-59
Number of pages	8
Journal	Experimental Neurology
Volume	91
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(86)90025-7
State	Published - Jan 1986
Externally published	Yes

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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title = "Regeneration of rat optic axons into peripheral nerve grafts",

abstract = "The regenerative response of myelinated axons of the mammalian central nervous system was investigated by inserting peripheral nerve grafts in the vicinity of traumatized rat optic axons. Peroneal nerve grafts were inserted into crushed optic nerves and assessed for the ability to support optic axon regeneration. Regenerating axons of retinal origin were present in the peripheral nerve grafts several weeks later. Horseradish peroxidase studies indicated that retinal ganglion cells were a source for regenerating nerve fibers.",

author = "Politis, {M. J.} and Spencer, {P. S.}",

note = "Funding Information: {\textquoteright} The technical services of Monica Bischoff and Rose Acompanado are gratefully appreciated. In addition, the authors thank Brenda Bell and Brenda Peters for preparation of this manuscript. This work was supported in part by a grant from the Medical Research Council of Canada (MRC Scholarship 57 19). Please address correspondence to Dr. Politis, University of Saskatchewan.",

year = "1986",

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doi = "10.1016/0014-4886(86)90025-7",

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T1 - Regeneration of rat optic axons into peripheral nerve grafts

AU - Politis, M. J.

AU - Spencer, P. S.

N1 - Funding Information: ’ The technical services of Monica Bischoff and Rose Acompanado are gratefully appreciated. In addition, the authors thank Brenda Bell and Brenda Peters for preparation of this manuscript. This work was supported in part by a grant from the Medical Research Council of Canada (MRC Scholarship 57 19). Please address correspondence to Dr. Politis, University of Saskatchewan.

PY - 1986/1

Y1 - 1986/1

N2 - The regenerative response of myelinated axons of the mammalian central nervous system was investigated by inserting peripheral nerve grafts in the vicinity of traumatized rat optic axons. Peroneal nerve grafts were inserted into crushed optic nerves and assessed for the ability to support optic axon regeneration. Regenerating axons of retinal origin were present in the peripheral nerve grafts several weeks later. Horseradish peroxidase studies indicated that retinal ganglion cells were a source for regenerating nerve fibers.

AB - The regenerative response of myelinated axons of the mammalian central nervous system was investigated by inserting peripheral nerve grafts in the vicinity of traumatized rat optic axons. Peroneal nerve grafts were inserted into crushed optic nerves and assessed for the ability to support optic axon regeneration. Regenerating axons of retinal origin were present in the peripheral nerve grafts several weeks later. Horseradish peroxidase studies indicated that retinal ganglion cells were a source for regenerating nerve fibers.

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JO - Experimental Neurology

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Regeneration of rat optic axons into peripheral nerve grafts

Abstract

ASJC Scopus subject areas

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