Regeneration of rat optic axons into peripheral nerve grafts

M. J. Politis, Peter Spencer

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The regenerative response of myelinated axons of the mammalian central nervous system was investigated by inserting peripheral nerve grafts in the vicinity of traumatized rat optic axons. Peroneal nerve grafts were inserted into crushed optic nerves and assessed for the ability to support optic axon regeneration. Regenerating axons of retinal origin were present in the peripheral nerve grafts several weeks later. Horseradish peroxidase studies indicated that retinal ganglion cells were a source for regenerating nerve fibers.

Original languageEnglish (US)
Pages (from-to)52-59
Number of pages8
JournalExperimental Neurology
Volume91
Issue number1
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Peripheral Nerves
Axons
Regeneration
Transplants
Peroneal Nerve
Retinal Ganglion Cells
Horseradish Peroxidase
Optic Nerve
Nerve Fibers
Central Nervous System

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Regeneration of rat optic axons into peripheral nerve grafts. / Politis, M. J.; Spencer, Peter.

In: Experimental Neurology, Vol. 91, No. 1, 1986, p. 52-59.

Research output: Contribution to journalArticle

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