Regeneration of rat optic axons into peripheral nerve grafts

M. J. Politis, P. S. Spencer

Research output: Contribution to journalArticle

48 Scopus citations


The regenerative response of myelinated axons of the mammalian central nervous system was investigated by inserting peripheral nerve grafts in the vicinity of traumatized rat optic axons. Peroneal nerve grafts were inserted into crushed optic nerves and assessed for the ability to support optic axon regeneration. Regenerating axons of retinal origin were present in the peripheral nerve grafts several weeks later. Horseradish peroxidase studies indicated that retinal ganglion cells were a source for regenerating nerve fibers.

Original languageEnglish (US)
Pages (from-to)52-59
Number of pages8
JournalExperimental Neurology
Issue number1
StatePublished - Jan 1986

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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