Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate

June Liu, Laura E. Pascal, Sudhir Isharwal, Daniel Metzger, Raquel Ramos Garcia, Jan Pilch, Susan Kasper, Karin Williams, Per H. Basse, Joel B. Nelson, Pierre Chambon, Zhou Wang

    Research output: Contribution to journalArticlepeer-review

    58 Scopus citations

    Abstract

    Determining the source of regenerated luminal epithelial cells in the adult prostate during androgen deprivation and replacement will provide insights into the origin of prostate cancer cells and their fate during androgen deprivation therapy. Prostate stem cells in the epithelial layer have been suggested to give rise to luminal epithelium. However, the extent of stem cell participation to prostate regrowth is not clear. In this report, using prostate-specific antigen-CreER T2-based genetic lineage marking/ tracing in mice, preexisting luminal epithelial cells were shown to be a source of regenerated luminal epithelial cells in the adult prostate. Prostatic luminal epithelial cells could survive androgen deprivation and were capable of proliferating upon androgen replacement. Prostate cancer cells, typically exhibiting a luminal epithelial phenotype, may retain this intrinsic capability to survive and regenerate in response to changes in androgen signaling, providing part of the mechanism for the ultimate failure of androgen deprivation therapy in prostate cancer.

    Original languageEnglish (US)
    Pages (from-to)1849-1857
    Number of pages9
    JournalMolecular Endocrinology
    Volume25
    Issue number11
    DOIs
    StatePublished - Nov 1 2011

    ASJC Scopus subject areas

    • Molecular Biology
    • Endocrinology

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