Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate

June Liu, Laura E. Pascal, Sudhir Isharwal, Daniel Metzger, Raquel Ramos Garcia, Jan Pilch, Susan Kasper, Karin Williams, Per H. Basse, Joel B. Nelson, Pierre Chambon, Zhou Wang

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Determining the source of regenerated luminal epithelial cells in the adult prostate during androgen deprivation and replacement will provide insights into the origin of prostate cancer cells and their fate during androgen deprivation therapy. Prostate stem cells in the epithelial layer have been suggested to give rise to luminal epithelium. However, the extent of stem cell participation to prostate regrowth is not clear. In this report, using prostate-specific antigen-CreER T2-based genetic lineage marking/ tracing in mice, preexisting luminal epithelial cells were shown to be a source of regenerated luminal epithelial cells in the adult prostate. Prostatic luminal epithelial cells could survive androgen deprivation and were capable of proliferating upon androgen replacement. Prostate cancer cells, typically exhibiting a luminal epithelial phenotype, may retain this intrinsic capability to survive and regenerate in response to changes in androgen signaling, providing part of the mechanism for the ultimate failure of androgen deprivation therapy in prostate cancer.

Original languageEnglish (US)
Pages (from-to)1849-1857
Number of pages9
JournalMolecular Endocrinology
Volume25
Issue number11
DOIs
StatePublished - Nov 1 2011
Externally publishedYes

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Androgens
Prostate
Epithelial Cells
Prostatic Neoplasms
Stem Cells
Prostate-Specific Antigen
Epithelium
Phenotype
Therapeutics

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Cite this

Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate. / Liu, June; Pascal, Laura E.; Isharwal, Sudhir; Metzger, Daniel; Garcia, Raquel Ramos; Pilch, Jan; Kasper, Susan; Williams, Karin; Basse, Per H.; Nelson, Joel B.; Chambon, Pierre; Wang, Zhou.

In: Molecular Endocrinology, Vol. 25, No. 11, 01.11.2011, p. 1849-1857.

Research output: Contribution to journalArticle

Liu, J, Pascal, LE, Isharwal, S, Metzger, D, Garcia, RR, Pilch, J, Kasper, S, Williams, K, Basse, PH, Nelson, JB, Chambon, P & Wang, Z 2011, 'Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate', Molecular Endocrinology, vol. 25, no. 11, pp. 1849-1857. https://doi.org/10.1210/me.2011-1081
Liu, June ; Pascal, Laura E. ; Isharwal, Sudhir ; Metzger, Daniel ; Garcia, Raquel Ramos ; Pilch, Jan ; Kasper, Susan ; Williams, Karin ; Basse, Per H. ; Nelson, Joel B. ; Chambon, Pierre ; Wang, Zhou. / Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate. In: Molecular Endocrinology. 2011 ; Vol. 25, No. 11. pp. 1849-1857.
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