Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans

David Matuskey, Zubin Bhagwagar, Beata Planeta, Brian Pittman, Jean Dominique Gallezot, Jason Chen, Jane Wanyiri, Soheila Najafzadeh, Jim Ropchan, Paul Geha, Yiyun Huang, Marc N. Potenza, Alexander Neumeister, Richard E. Carson, Robert T. Malison

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: Preclinical evidence implicates the serotonin receptor 5-hydroxytryptamine 1B (5-HT1B) in the effects of cocaine. This study explores 5-HT1B in humans by examining receptor availability in vivo in subjects whose primary addiction is cocaine dependence (CD) using positron emission tomography.

Original languageEnglish (US)
Pages (from-to)816-822
Number of pages7
JournalBiological Psychiatry
Volume76
Issue number10
DOIs
StatePublished - 2014

Keywords

  • 5-HT
  • Cocaine
  • Human
  • PET
  • Serotonin
  • VBM

ASJC Scopus subject areas

  • Biological Psychiatry

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    Matuskey, D., Bhagwagar, Z., Planeta, B., Pittman, B., Gallezot, J. D., Chen, J., Wanyiri, J., Najafzadeh, S., Ropchan, J., Geha, P., Huang, Y., Potenza, M. N., Neumeister, A., Carson, R. E., & Malison, R. T. (2014). Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans. Biological Psychiatry, 76(10), 816-822. https://doi.org/10.1016/j.biopsych.2013.11.022