Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans

David Matuskey; Zubin Bhagwagar; Beata Planeta; Brian Pittman; Jean Dominique Gallezot; Jason Chen; Jane Wanyiri; Soheila Najafzadeh; Jim Ropchan; Paul Geha; Yiyun Huang; Marc N. Potenza; Alexander Neumeister; Richard E. Carson; Robert T. Malison

doi:10.1016/j.biopsych.2013.11.022

Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans

David Matuskey, Zubin Bhagwagar, Beata Planeta, Brian Pittman, Jean Dominique Gallezot, Jason Chen, Jane Wanyiri, Soheila Najafzadeh, Jim Ropchan, Paul Geha, Yiyun Huang, Marc N. Potenza, Alexander Neumeister, Richard E. Carson, Robert T. Malison

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Background: Preclinical evidence implicates the serotonin receptor 5-hydroxytryptamine 1B (5-HT_1B) in the effects of cocaine. This study explores 5-HT_1B in humans by examining receptor availability in vivo in subjects whose primary addiction is cocaine dependence (CD) using positron emission tomography.

Original language	English (US)
Pages (from-to)	816-822
Number of pages	7
Journal	Biological Psychiatry
Volume	76
Issue number	10
DOIs	https://doi.org/10.1016/j.biopsych.2013.11.022
State	Published - 2014
Externally published	Yes

Keywords

5-HT
Cocaine
Human
PET
Serotonin
VBM

ASJC Scopus subject areas

Biological Psychiatry

Access to Document

10.1016/j.biopsych.2013.11.022

Cite this

Matuskey, D., Bhagwagar, Z., Planeta, B., Pittman, B., Gallezot, J. D., Chen, J., Wanyiri, J., Najafzadeh, S., Ropchan, J., Geha, P., Huang, Y., Potenza, M. N., Neumeister, A., Carson, R. E., & Malison, R. T. (2014). Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans. Biological Psychiatry, 76(10), 816-822. https://doi.org/10.1016/j.biopsych.2013.11.022

Matuskey, D, Bhagwagar, Z, Planeta, B, Pittman, B, Gallezot, JD, Chen, J, Wanyiri, J, Najafzadeh, S, Ropchan, J, Geha, P, Huang, Y, Potenza, MN, Neumeister, A, Carson, RE & Malison, RT 2014, 'Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans', Biological Psychiatry, vol. 76, no. 10, pp. 816-822. https://doi.org/10.1016/j.biopsych.2013.11.022

@article{f7eefcae7254455a8fb8b48063aa423e,

title = "Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans",

abstract = "Background: Preclinical evidence implicates the serotonin receptor 5-hydroxytryptamine 1B (5-HT1B) in the effects of cocaine. This study explores 5-HT1B in humans by examining receptor availability in vivo in subjects whose primary addiction is cocaine dependence (CD) using positron emission tomography.",

keywords = "5-HT, Cocaine, Human, PET, Serotonin, VBM",

author = "David Matuskey and Zubin Bhagwagar and Beata Planeta and Brian Pittman and Gallezot, {Jean Dominique} and Jason Chen and Jane Wanyiri and Soheila Najafzadeh and Jim Ropchan and Paul Geha and Yiyun Huang and Potenza, {Marc N.} and Alexander Neumeister and Carson, {Richard E.} and Malison, {Robert T.}",

note = "Publisher Copyright: {\textcopyright} 2014 Society of Biological Psychiatry.",

year = "2014",

doi = "10.1016/j.biopsych.2013.11.022",

language = "English (US)",

volume = "76",

pages = "816--822",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier USA",

number = "10",

}

TY - JOUR

T1 - Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans

AU - Matuskey, David

AU - Bhagwagar, Zubin

AU - Planeta, Beata

AU - Pittman, Brian

AU - Gallezot, Jean Dominique

AU - Chen, Jason

AU - Wanyiri, Jane

AU - Najafzadeh, Soheila

AU - Ropchan, Jim

AU - Geha, Paul

AU - Huang, Yiyun

AU - Potenza, Marc N.

AU - Neumeister, Alexander

AU - Carson, Richard E.

AU - Malison, Robert T.

PY - 2014

Y1 - 2014

N2 - Background: Preclinical evidence implicates the serotonin receptor 5-hydroxytryptamine 1B (5-HT1B) in the effects of cocaine. This study explores 5-HT1B in humans by examining receptor availability in vivo in subjects whose primary addiction is cocaine dependence (CD) using positron emission tomography.

AB - Background: Preclinical evidence implicates the serotonin receptor 5-hydroxytryptamine 1B (5-HT1B) in the effects of cocaine. This study explores 5-HT1B in humans by examining receptor availability in vivo in subjects whose primary addiction is cocaine dependence (CD) using positron emission tomography.

KW - 5-HT

KW - Cocaine

KW - Human

KW - PET

KW - Serotonin

KW - VBM

UR - http://www.scopus.com/inward/record.url?scp=84927912526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927912526&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2013.11.022

DO - 10.1016/j.biopsych.2013.11.022

M3 - Article

C2 - 24433854

AN - SCOPUS:84927912526

SN - 0006-3223

VL - 76

SP - 816

EP - 822

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 10

ER -

Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this