Altered metabolism has long been recognized as a hallmark of cancer,1 but recently, the direct effect of metabolites on epigenetic regulation has become more appreciated. In this issue of Blood, Jiang et al2 use a mouse model of acute myeloid leukemia (AML) to show that the metabolic regulator adenosine monophosphate–activated protein kinase (AMPK) controls acetyl-coenzyme A (acetyl-CoA) homeostasis.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Dec 12 2019|
ASJC Scopus subject areas
- Cell Biology