Reducing acetyl-CoA enhances BET inhibition

Research output: Contribution to journalReview articlepeer-review

Abstract

Altered metabolism has long been recognized as a hallmark of cancer,1 but recently, the direct effect of metabolites on epigenetic regulation has become more appreciated. In this issue of Blood, Jiang et al2 use a mouse model of acute myeloid leukemia (AML) to show that the metabolic regulator adenosine monophosphate–activated protein kinase (AMPK) controls acetyl-coenzyme A (acetyl-CoA) homeostasis.

Original languageEnglish (US)
Pages (from-to)2122-2123
Number of pages2
JournalBlood
Volume134
Issue number24
DOIs
StatePublished - Dec 12 2019

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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