Reducing acetyl-CoA enhances BET inhibition

Elie Traer

doi:10.1182/blood.2019003653

Reducing acetyl-CoA enhances BET inhibition

Elie Traer

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Altered metabolism has long been recognized as a hallmark of cancer,¹ but recently, the direct effect of metabolites on epigenetic regulation has become more appreciated. In this issue of Blood, Jiang et al² use a mouse model of acute myeloid leukemia (AML) to show that the metabolic regulator adenosine monophosphate–activated protein kinase (AMPK) controls acetyl-coenzyme A (acetyl-CoA) homeostasis.

Original language	English (US)
Pages (from-to)	2122-2123
Number of pages	2
Journal	Blood
Volume	134
Issue number	24
DOIs	https://doi.org/10.1182/blood.2019003653
State	Published - Dec 12 2019

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood.2019003653

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title = "Reducing acetyl-CoA enhances BET inhibition",

abstract = "Altered metabolism has long been recognized as a hallmark of cancer,1 but recently, the direct effect of metabolites on epigenetic regulation has become more appreciated. In this issue of Blood, Jiang et al2 use a mouse model of acute myeloid leukemia (AML) to show that the metabolic regulator adenosine monophosphate–activated protein kinase (AMPK) controls acetyl-coenzyme A (acetyl-CoA) homeostasis.",

author = "Elie Traer",

note = "Publisher Copyright: {\textcopyright} 2019 by The American Society of Hematology",

year = "2019",

month = dec,

day = "12",

doi = "10.1182/blood.2019003653",

language = "English (US)",

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AU - Traer, Elie

PY - 2019/12/12

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N2 - Altered metabolism has long been recognized as a hallmark of cancer,1 but recently, the direct effect of metabolites on epigenetic regulation has become more appreciated. In this issue of Blood, Jiang et al2 use a mouse model of acute myeloid leukemia (AML) to show that the metabolic regulator adenosine monophosphate–activated protein kinase (AMPK) controls acetyl-coenzyme A (acetyl-CoA) homeostasis.

AB - Altered metabolism has long been recognized as a hallmark of cancer,1 but recently, the direct effect of metabolites on epigenetic regulation has become more appreciated. In this issue of Blood, Jiang et al2 use a mouse model of acute myeloid leukemia (AML) to show that the metabolic regulator adenosine monophosphate–activated protein kinase (AMPK) controls acetyl-coenzyme A (acetyl-CoA) homeostasis.

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DO - 10.1182/blood.2019003653

M3 - Review article

C2 - 31830279

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JO - Blood

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ER -

Reducing acetyl-CoA enhances BET inhibition

Abstract

ASJC Scopus subject areas

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