Reduced presynaptic dopamine activity in adolescent dorsal striatum

Marguerite Matthews, Corina Bondi, Gonzalo Torres, Bita Moghaddam

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Adolescence coincides with symptomatic onset of several psychiatric illnesses including schizophrenia and addiction. Excess limbic dopamine activity has been implicated in these vulnerabilities. We combined molecular and dynamic indices of dopamine neurotransmission to assess dopamine function in adolescent rats in two functionally distinct striatal subregions: nucleus accumbens (NAc) and dorsal striatum (DS). In adolescents, we find an overall reduction in dopamine availability selective to the DS. Dopamine release in the DS, but not in the NAc, was less responsive to amphetamine in adolescents compared to adults. The dopamine transporter (DAT) inhibitor, nomifensine, similarly inhibited basal and amphetamine-induced dopamine release in either regions of both the age groups, suggesting that the reduced effectiveness of amphetamine is not due to differences in DAT function. Furthermore, DAT and vesicular monoamine transporter-2 expressions were similar in the DS and NAc of adolescent rats. In contrast, expression of tyrosine hydroxylase (TH) was reduced in the DS, but not in the NAc, of adolescents compared to adults. Behaviorally, adolescents were less sensitive to amphetamine but more sensitive to a TH inhibitor. These data indicate that, in contrast to the general notion that dopamine is hyperactive in adolescents, there is diminished presynaptic dopamine activity in adolescents that is selective to the DS and may result from attenuated TH activity. Given recent reports of altered dopamine activity in associative/dorsal striatum of individuals at a clinically high risk of psychosis, our data further support the idea that dorsal, as opposed to ventral, regions of the striatum are a locus of vulnerability for psychosis.

Original languageEnglish (US)
Pages (from-to)1344-1351
Number of pages8
JournalNeuropsychopharmacology
Volume38
Issue number7
DOIs
StatePublished - Jun 2013
Externally publishedYes

Fingerprint

Dopamine
Nucleus Accumbens
Amphetamine
Dopamine Plasma Membrane Transport Proteins
Tyrosine 3-Monooxygenase
Psychotic Disorders
Vesicular Monoamine Transport Proteins
Nomifensine
Corpus Striatum
Molecular Dynamics Simulation
Synaptic Transmission
Psychiatry
Schizophrenia
Age Groups

Keywords

  • addiction
  • amphetamine
  • learning
  • nucleus accumbens
  • schizophrenia
  • tyrosine hydroxylase

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Reduced presynaptic dopamine activity in adolescent dorsal striatum. / Matthews, Marguerite; Bondi, Corina; Torres, Gonzalo; Moghaddam, Bita.

In: Neuropsychopharmacology, Vol. 38, No. 7, 06.2013, p. 1344-1351.

Research output: Contribution to journalArticle

Matthews, Marguerite ; Bondi, Corina ; Torres, Gonzalo ; Moghaddam, Bita. / Reduced presynaptic dopamine activity in adolescent dorsal striatum. In: Neuropsychopharmacology. 2013 ; Vol. 38, No. 7. pp. 1344-1351.
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