Recombinant human inhibin-A administered early in the menstrual cycle alters concurrent pituitary and follicular, plus subsequent luteal, function in rhesus monkeys

Theodore A. Molskness, Teresa K. Woodruff, David Hess, Kristine D. Dahl, Richard Stouffer

    Research output: Contribution to journalArticle

    54 Citations (Scopus)

    Abstract

    Inhibin, a suppressor of pituitary FSH secretion in nonprimate species, may also act in the ovary to regulate follicular development. To examine whether inhibin has similar actions in primates, female rhesus monkeys (n = 3/treatment), exhibiting regular menstrual cycles, received sc injections of either vehicle or 60 μg/kg recombinant human inhibin-A at 0800 and 1600 h for 5 days beginning at menses. The vehicle-treated monkeys displayed menstrual cycles of normal length, with the follicular (11.3 ± 2.5 days, mean ± SE) and luteal (16.3 ± 2.5 days) phases demarcated by midcycle peaks in serum estradiol (E) and bioactive LH. After the first inhibin injection, levels of immunoreactive inhibin A peaked at 10 ng/mL within 1 h and returned to baseline (

    Original languageEnglish (US)
    Pages (from-to)4002-4006
    Number of pages5
    JournalJournal of Clinical Endocrinology and Metabolism
    Volume81
    Issue number11
    DOIs
    StatePublished - 1996

    Fingerprint

    Inhibins
    Corpus Luteum
    Menstrual Cycle
    Macaca mulatta
    Injections
    Menstruation
    Primates
    Haplorhini
    Ovary
    Estradiol
    Serum
    inhibin A
    Therapeutics

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Recombinant human inhibin-A administered early in the menstrual cycle alters concurrent pituitary and follicular, plus subsequent luteal, function in rhesus monkeys. / Molskness, Theodore A.; Woodruff, Teresa K.; Hess, David; Dahl, Kristine D.; Stouffer, Richard.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 81, No. 11, 1996, p. 4002-4006.

    Research output: Contribution to journalArticle

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    AU - Hess, David

    AU - Dahl, Kristine D.

    AU - Stouffer, Richard

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