Reciprocal changes in fructose-6-phosphate,2-kinase and fructose-2,6-bisphosphatase activity in response to glucagon and epinephrine

Carolyn Sue Richards, Motoko Yokoyama, Eisuke Furuya, Kosaku Uyeda

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25 Scopus citations


The effect of hormones on the enzymes responsible for the synthesis (fructose-6-P,2-kinase) and degradation (fructose-2,6-Pase) of fructose-2,6-P2 was examined in isolated rat hepatocytes. Glucagon (10-11 M), epinephrine (10-5 M), or calcium (2.4 mM) and A23187 (10-5 M) administration to hepatocytes produced simultaneous activation of fructose-2,6-Pase and inactivation of fructose-6-P,2-kinase within 2 minutes. The effect of epinephrine on these two enzymes was dependent on the presence of Ca++. These results suggest that the level of fructose-2,6-P2 is controlled by recriprocal changes in fructose-2,6-Pase and fructose-6-P,2-kinase activities.

Original languageEnglish (US)
Pages (from-to)1073-1079
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Feb 11 1982


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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