Recent developments in therapeutic cancer vaccines

Michael A. Morse, Stephen Chui, Amy Hobeika, H. Kim Lyerly, Timothy Clay

    Research output: Contribution to journalReview article

    39 Scopus citations

    Abstract

    Therapeutic cancer vaccines ae being developed with the intention of treating existing tumors or preventing tumor recurrence. While the results of clinical trials, predominantly in the metastatic setting have been sobering, the central hypothesis of active immunotherapy i.e. that the human immune system can be activated to recognize and destroy tumor cells, remains a viable one. We believe that a fundamental shift in how clinical trials are performed, and what concepts they test is required to make meaningful strides towards future clinical use of cancer vaccines. First, we must reappraise whether the metastatic setting is the appropriate arena to test these agents. Second, we must arrive at a consensus on the most important biologic endpoints and rapidly test vaccines for their ability to achieve these endpoints. Third, we need to expend more effort on understanding how to manipulate the immune system beyond the initial stimulation provided by a vaccine. Fourth, in order to permit comparison of results across different studies, it would be helpful to narrow down the large number of vaccine platforms. We will discuss the current state of development of cancer vaccines and the relevance for future clinical use of these agents to treat and prevent cancers.

    Original languageEnglish (US)
    Pages (from-to)108-113
    Number of pages6
    JournalNature Clinical Practice Oncology
    Volume2
    Issue number2
    DOIs
    StatePublished - Feb 1 2005

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    Keywords

    • Antibody
    • Dendritic cell
    • Immunotherapy
    • T cell
    • Viral vector

    ASJC Scopus subject areas

    • Oncology

    Cite this

    Morse, M. A., Chui, S., Hobeika, A., Lyerly, H. K., & Clay, T. (2005). Recent developments in therapeutic cancer vaccines. Nature Clinical Practice Oncology, 2(2), 108-113. https://doi.org/10.1038/ncponc0098