Recent advances in the genetics of parkinson's disease

Ian Martin, Valina L. Dawson, Ted M. Dawson

Research output: Contribution to journalArticle

267 Scopus citations

Abstract

Genetic studies have provided valuable insight into the pathological mechanisms underlying Parkinson's disease (PD). The elucidation of genetic components to what was once largely considered a nongenetic disease has given rise to a multitude of cell and animal models enabling the dissection of molecular pathways involved in disease etiology. Here, we review advances obtained from models of dominant mutations in α-synuclein and LRRK2 as well as recessive PINK1, parkin and DJ-1 mutations. Recent genome-wide association studies have implicated genetic variability at two of these loci, α-synuclein and LRRK2, as significant risk factors for developing sporadic PD. This, coupled with the established role of mitochondrial impairment in both familial and sporadic PD, highlights the likelihood of common mechanisms fundamental to the etiology of both.

Original languageEnglish (US)
Pages (from-to)301-325
Number of pages25
JournalAnnual Review of Genomics and Human Genetics
Volume12
DOIs
StatePublished - Jul 13 2011

Keywords

  • DJ-1
  • LRRK2
  • PARIS
  • PINK1
  • parkin
  • α-synuclein

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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