Recent advances in factors that alter lipid metabolism in chronic renal failure

T. Drueke, B. Lacour, Jean-Baptiste Roullet, J. L. Funck-Brentano

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The following conclusions and speculations can be tentatively drawn from the changes in lipoprotein composition and metabolism: (1) The presence of apo B-48 in serum VLDL and the high serum apo A-IV concentrations indicate a greater than normal contribution of alimentary remnant particles to the hypertriglyceridemia of uremic patients. (2) The presence of apo E and C in triglyceride-enriched serum LDL, together with the triglyceride enrichment of all lipoproteins, probably stems from a deficiency of lipoprotein lipase (LPL) and hepatic lipase (HL) activity. (3) The decreased ratio of serum apo C-II/C-III in VLDL is at least in part responsible for the depressed activity of LPL. (4) The accumulation of lipoprotein particles with distorted apoprotein and lipid patterns (particularly β-VLDL with enrichment in cholesterol) could be associated with an increased atherogenesis because a recent study has demonstrated a strong association between raised serum IDL and VLDL concentrations and the degree of coronary atherosclerosis. (5) The increased apo E content of VLDL and HDL in uremic patients could particularly point to a disturbed cholesterol metabolism because such lipoproteins could interact with LDL at apo B, E receptors. (6) The decrease in serum HDL-cholesterol has been shown to be strongly associated with atheromatous vascular disease, and this could also hold for uremic patients; however, it is probable that low serum HDL-cholesterol together with a diminished capacity to form cholesterol-rich, apo E containing HDL represents a decrease in the antiatherogenic defense of the organism rather than an increased atherogenic potential.

Original languageEnglish (US)
JournalKidney International
Volume24
Issue numberSUPPL. 16
StatePublished - 1983
Externally publishedYes

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Lipid Metabolism
Chronic Kidney Failure
Lipoproteins
Apolipoproteins E
Serum
Cholesterol
Triglycerides
Hypoalphalipoproteinemias
Hyperlipoproteinemia Type I
Apolipoprotein C-II
Apolipoprotein B-48
Apolipoproteins C
Apoproteins
Lipoprotein Lipase
Hypertriglyceridemia
Lipase
Vascular Diseases
HDL Cholesterol
Coronary Artery Disease
Atherosclerosis

ASJC Scopus subject areas

  • Nephrology

Cite this

Drueke, T., Lacour, B., Roullet, J-B., & Funck-Brentano, J. L. (1983). Recent advances in factors that alter lipid metabolism in chronic renal failure. Kidney International, 24(SUPPL. 16).

Recent advances in factors that alter lipid metabolism in chronic renal failure. / Drueke, T.; Lacour, B.; Roullet, Jean-Baptiste; Funck-Brentano, J. L.

In: Kidney International, Vol. 24, No. SUPPL. 16, 1983.

Research output: Contribution to journalArticle

Drueke, T, Lacour, B, Roullet, J-B & Funck-Brentano, JL 1983, 'Recent advances in factors that alter lipid metabolism in chronic renal failure', Kidney International, vol. 24, no. SUPPL. 16.
Drueke T, Lacour B, Roullet J-B, Funck-Brentano JL. Recent advances in factors that alter lipid metabolism in chronic renal failure. Kidney International. 1983;24(SUPPL. 16).
Drueke, T. ; Lacour, B. ; Roullet, Jean-Baptiste ; Funck-Brentano, J. L. / Recent advances in factors that alter lipid metabolism in chronic renal failure. In: Kidney International. 1983 ; Vol. 24, No. SUPPL. 16.
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