Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp.

Serge Fotso, Taifo Mahmud, T. Mark Zabriskie, Dwi Andreas Santosa, Sulastri, Philip J. Proteau

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Two Indonesian Streptomyces strains, ICBB8309 and ICBB8415, were investigated for their ability to produce antibiotic compounds. In addition to the known antibiotics actiphenol, naramycin B, and sabaramycin, six new angucyclinones were identified. The isolation, structure elucidation and biological activities for the six new compounds are presented. The angucyclinones 7-deoxo-6-deoxy-7-hydroxy-8-O-methylrabelomycin, 1-deoxo-1-hydroxy-8-O-methylrabelomycin, and the angucycline 7-deoxo-7-hydroxy-1-O-α-rhamnosyl-8-O-methyltetrangulol have common angular backbones, while angucyclinone C, limamycin A, and limamycin B appear to be rearranged angucyclinones.

Original languageEnglish (US)
Pages (from-to)449-456
Number of pages8
JournalJournal of Antibiotics
Volume61
Issue number7
DOIs
StatePublished - Jul 1 2008

Keywords

  • Angucyclinone
  • Antibiotics
  • MTT assay
  • Polyketide
  • Streptomyces metabolites

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Fotso, S., Mahmud, T., Zabriskie, T. M., Santosa, D. A., Sulastri, & Proteau, P. J. (2008). Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp. Journal of Antibiotics, 61(7), 449-456. https://doi.org/10.1038/ja.2008.61