Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp.

Serge Fotso; Taifo Mahmud; T. Mark Zabriskie; Dwi Andreas Santosa; Sulastri; Philip J. Proteau

doi:10.1038/ja.2008.61

Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp.

Serge Fotso, Taifo Mahmud, T. Mark Zabriskie, Dwi Andreas Santosa, Sulastri, Philip J. Proteau

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Two Indonesian Streptomyces strains, ICBB8309 and ICBB8415, were investigated for their ability to produce antibiotic compounds. In addition to the known antibiotics actiphenol, naramycin B, and sabaramycin, six new angucyclinones were identified. The isolation, structure elucidation and biological activities for the six new compounds are presented. The angucyclinones 7-deoxo-6-deoxy-7-hydroxy-8-O-methylrabelomycin, 1-deoxo-1-hydroxy-8-O-methylrabelomycin, and the angucycline 7-deoxo-7-hydroxy-1-O-α-rhamnosyl-8-O-methyltetrangulol have common angular backbones, while angucyclinone C, limamycin A, and limamycin B appear to be rearranged angucyclinones.

Original language	English (US)
Pages (from-to)	449-456
Number of pages	8
Journal	Journal of Antibiotics
Volume	61
Issue number	7
DOIs	https://doi.org/10.1038/ja.2008.61
State	Published - Jul 2008
Externally published	Yes

Keywords

Angucyclinone
Antibiotics
MTT assay
Polyketide
Streptomyces metabolites

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/ja.2008.61

Cite this

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title = "Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp.",

abstract = "Two Indonesian Streptomyces strains, ICBB8309 and ICBB8415, were investigated for their ability to produce antibiotic compounds. In addition to the known antibiotics actiphenol, naramycin B, and sabaramycin, six new angucyclinones were identified. The isolation, structure elucidation and biological activities for the six new compounds are presented. The angucyclinones 7-deoxo-6-deoxy-7-hydroxy-8-O-methylrabelomycin, 1-deoxo-1-hydroxy-8-O-methylrabelomycin, and the angucycline 7-deoxo-7-hydroxy-1-O-α-rhamnosyl-8-O-methyltetrangulol have common angular backbones, while angucyclinone C, limamycin A, and limamycin B appear to be rearranged angucyclinones.",

keywords = "Angucyclinone, Antibiotics, MTT assay, Polyketide, Streptomyces metabolites",

author = "Serge Fotso and Taifo Mahmud and Zabriskie, {T. Mark} and Santosa, {Dwi Andreas} and Sulastri and Proteau, {Philip J.}",

note = "Funding Information: spectra (supported by a grant from NIEHS-ES00210) and Dr. Emily Ho for conducting the MTT assays. This work was supported by research funds from the College of Pharmacy, Oregon State University.",

year = "2008",

month = jul,

doi = "10.1038/ja.2008.61",

language = "English (US)",

volume = "61",

pages = "449--456",

journal = "Journal of Antibiotics",

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AU - Fotso, Serge

AU - Mahmud, Taifo

AU - Zabriskie, T. Mark

AU - Santosa, Dwi Andreas

AU - Sulastri,

AU - Proteau, Philip J.

N1 - Funding Information: spectra (supported by a grant from NIEHS-ES00210) and Dr. Emily Ho for conducting the MTT assays. This work was supported by research funds from the College of Pharmacy, Oregon State University.

PY - 2008/7

Y1 - 2008/7

N2 - Two Indonesian Streptomyces strains, ICBB8309 and ICBB8415, were investigated for their ability to produce antibiotic compounds. In addition to the known antibiotics actiphenol, naramycin B, and sabaramycin, six new angucyclinones were identified. The isolation, structure elucidation and biological activities for the six new compounds are presented. The angucyclinones 7-deoxo-6-deoxy-7-hydroxy-8-O-methylrabelomycin, 1-deoxo-1-hydroxy-8-O-methylrabelomycin, and the angucycline 7-deoxo-7-hydroxy-1-O-α-rhamnosyl-8-O-methyltetrangulol have common angular backbones, while angucyclinone C, limamycin A, and limamycin B appear to be rearranged angucyclinones.

AB - Two Indonesian Streptomyces strains, ICBB8309 and ICBB8415, were investigated for their ability to produce antibiotic compounds. In addition to the known antibiotics actiphenol, naramycin B, and sabaramycin, six new angucyclinones were identified. The isolation, structure elucidation and biological activities for the six new compounds are presented. The angucyclinones 7-deoxo-6-deoxy-7-hydroxy-8-O-methylrabelomycin, 1-deoxo-1-hydroxy-8-O-methylrabelomycin, and the angucycline 7-deoxo-7-hydroxy-1-O-α-rhamnosyl-8-O-methyltetrangulol have common angular backbones, while angucyclinone C, limamycin A, and limamycin B appear to be rearranged angucyclinones.

KW - Angucyclinone

KW - Antibiotics

KW - MTT assay

KW - Polyketide

KW - Streptomyces metabolites

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JO - Journal of Antibiotics

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ER -

Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp.

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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