Real-Time 3-Dimensional Echocardiographic Assessment of Ventricular Volume, Mass, and Function in Human Fetuses

Minjuan Zheng, Micheal Schaal, Yan Chen, Xiaokui Li, Weihui Shentu, Pengyuan Zhang, Muhammad Ashraf, Shuping Ge, David Sahn

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: We sought to determine the feasibility and reproducibility of real-time 3-dimensional echocardiography (RT3DE) for evaluation of cardiac volume, mass, and function and to characterize maturational changes of these measurements in human fetuses. Methods: Eighty pregnant women in the 2nd and 3rd trimesters (59 with normal fetuses and 21 with fetuses with congenital heart disease [CHD]) were enrolled. We acquired RT3DE images using a matrix-array transducer. RT3DE measurements of volume, mass, stroke volume (SV), combined cardiac output (CCO), and ejection fraction (EF) were obtained. Images were scored and analyzed by two blinded independent observers. Inter- and intraobserver variabilities and correlations between fetal cardiac indices and gestational age were determined. Results: Fifty-two of 59 normal data sets (88%) and 9 of 21 CHD data sets (43%) were feasible for analysis. In normal fetuses, the right ventricle (RV) is larger than the left ventricle (LV) (P

Original languageEnglish (US)
Article numbere58494
JournalPLoS One
Volume8
Issue number3
DOIs
StatePublished - Mar 14 2013

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Echocardiography
fetus
echocardiography
Fetus
heart diseases
Heart Ventricles
Heart Diseases
Cardiac Volume
Observer Variation
gestational age
Transducers
pregnant women
cardiac output
stroke
Cardiac Output
reproducibility
Stroke Volume
Gestational Age
Pregnant Women
Datasets

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Real-Time 3-Dimensional Echocardiographic Assessment of Ventricular Volume, Mass, and Function in Human Fetuses. / Zheng, Minjuan; Schaal, Micheal; Chen, Yan; Li, Xiaokui; Shentu, Weihui; Zhang, Pengyuan; Ashraf, Muhammad; Ge, Shuping; Sahn, David.

In: PLoS One, Vol. 8, No. 3, e58494, 14.03.2013.

Research output: Contribution to journalArticle

Zheng, M, Schaal, M, Chen, Y, Li, X, Shentu, W, Zhang, P, Ashraf, M, Ge, S & Sahn, D 2013, 'Real-Time 3-Dimensional Echocardiographic Assessment of Ventricular Volume, Mass, and Function in Human Fetuses', PLoS One, vol. 8, no. 3, e58494. https://doi.org/10.1371/journal.pone.0058494
Zheng, Minjuan ; Schaal, Micheal ; Chen, Yan ; Li, Xiaokui ; Shentu, Weihui ; Zhang, Pengyuan ; Ashraf, Muhammad ; Ge, Shuping ; Sahn, David. / Real-Time 3-Dimensional Echocardiographic Assessment of Ventricular Volume, Mass, and Function in Human Fetuses. In: PLoS One. 2013 ; Vol. 8, No. 3.
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