Rapid regression of fetal adrenal zone and absence of adrenal reticular zone in the marmoset.

J. Levine, L. G. Wolfe, R. J. Schiebinger, Donald (Lynn) Loriaux, G. B. Cutler

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Developmental changes in plasma dehydropiandrosterone (DHA) and in adrenal histology were studied in several marmoset species (Callithrix jacchus and Saguinus labiatus, nigricollis, and fuscicollis) to evaluate these primates as experimental models for the study of fetal adrenal zone regression. Newborn marmosets had a prominent fetal adrenal zone, plasma DHA levels above 1000 ng/dl, and plasma DHA sulfate (DHAS) levels of 140 micrograms/dl. The fetal zone regressed dramatically during the first week of life, paralleled by a marked decline in plasma DHA, the plasma DHA to cortisol ratio, and plasma DHAS. The adult marmoset, however, had no adrenal reticular zone and no evidence of adrenal DHA secretion; DHA levels in castrate adults were undetectable (less than 25 ng/dl). Thus, the marmoset represents the first example of a primate that has a regressing, DHA- and DHAS-secreting fetal adrenal zone but that does not subsequently develop a DHA-secreting adrenal reticular zone.

Original languageEnglish (US)
Pages (from-to)1797-1802
Number of pages6
JournalEndocrinology
Volume111
Issue number6
StatePublished - Dec 1982
Externally publishedYes

Fingerprint

Callithrix
Dehydroepiandrosterone Sulfate
Primates
Saguinus
Sulfates
Hydrocortisone
Histology
Theoretical Models

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Levine, J., Wolfe, L. G., Schiebinger, R. J., Loriaux, D. L., & Cutler, G. B. (1982). Rapid regression of fetal adrenal zone and absence of adrenal reticular zone in the marmoset. Endocrinology, 111(6), 1797-1802.

Rapid regression of fetal adrenal zone and absence of adrenal reticular zone in the marmoset. / Levine, J.; Wolfe, L. G.; Schiebinger, R. J.; Loriaux, Donald (Lynn); Cutler, G. B.

In: Endocrinology, Vol. 111, No. 6, 12.1982, p. 1797-1802.

Research output: Contribution to journalArticle

Levine, J, Wolfe, LG, Schiebinger, RJ, Loriaux, DL & Cutler, GB 1982, 'Rapid regression of fetal adrenal zone and absence of adrenal reticular zone in the marmoset.', Endocrinology, vol. 111, no. 6, pp. 1797-1802.
Levine, J. ; Wolfe, L. G. ; Schiebinger, R. J. ; Loriaux, Donald (Lynn) ; Cutler, G. B. / Rapid regression of fetal adrenal zone and absence of adrenal reticular zone in the marmoset. In: Endocrinology. 1982 ; Vol. 111, No. 6. pp. 1797-1802.
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