Randomized trial of a dual-hormone artificial pancreas with dosing adjustment during exercise compared with no adjustment and sensor-augmented pump therapy

Peter Jacobs, Joseph El Youssef, R. Reddy, N. Resalat, D. Branigan, J. Condon, N. Preiser, K. Ramsey, M. Jones, C. Edwards, Kerry Kuehl, J. Leitschuh, U. Rajhbeharrysingh, Jessica Castle

Research output: Contribution to journalArticle

54 Scopus citations


Aims: To test whether adjusting insulin and glucagon in response to exercise within a dual-hormone artificial pancreas (AP) reduces exercise-related hypoglycaemia. Materials and methods: In random order, 21 adults with type 1 diabetes (T1D) underwent three 22-hour experimental sessions: AP with exercise dosing adjustment (APX); AP with no exercise dosing adjustment (APN); and sensor-augmented pump (SAP) therapy. After an overnight stay and 2hours after breakfast, participants exercised for 45minutes at 60% of their maximum heart rate, with no snack given before exercise. During APX, insulin was decreased and glucagon was increased at exercise onset, while during SAP therapy, subjects could adjust dosing before exercise. The two primary outcomes were percentage of time spent in hypoglycaemia (

Original languageEnglish (US)
JournalDiabetes, Obesity and Metabolism
Publication statusAccepted/In press - 2016



  • Artificial pancreas
  • Continuous glucose monitoring (CGM)
  • Exercise
  • Glucagon
  • Hypoglycaemia
  • Insulin delivery
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)
  • Endocrinology

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