Racial differences in the outcome of patients with urothelial carcinoma of the upper urinary tract: An international study

Kazumasa Matsumoto, Giacomo Novara, Amit Gupta, Vitaly Margulis, Thomas J. Walton, Marco Roscigno, Casey Ng, Eiji Kikuchi, Richard Zigeuner, Wassim Kassouf, Hans Martin Fritsche, Vincenzo Ficarra, Guido Martignoni, Stefan Tritschler, Joaquin Carballido Rodriguez, Christian Seitz, Alon Weizer, Mesut Remzi, Jay D. Raman, Christian BolenzKarim Bensalah, Theresa M. Koppie, Pierre I. Karakiewicz, Christopher G. Wood, Francesco Montorsi, Masatsugu Iwamura, Shahrokh F. Shariat

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? The differential effect of ethnicity on clinico-pathological features and cancer-related outcomes remains uninvestigated in upper tract urothelial carcinoma. Ethnicity was not an independent predictor of either recurrence or cancer-related death in upper tract urothelial carcinoma. OBJECTIVE • To assess the impact of differences in ethnicity on clinico-pathological characteristics and outcomes of patients with upper urinary tract urothelial carcinoma (UTUC) in a large multi-center series of patients treated with radical nephroureterectomy (RNU). MATERIALS AND METHODS • We retrospectively collected the data of 2163 patients treated with RNU at 20 academic centres in America, Asia, and Europe. • Univariable and multivariable Cox regression models addressed recurrence-free survival (RFS) and cancer-specific survival (CSS). RESULTS • In all, 1794 (83%) patients were Caucasian and 369 (17%) were Japanese. All the main clinical and pathological features were significantly different between the two ethnicities. • The median follow-up of the whole cohort was 36 months. At last follow-up, 554 patients (26%) developed disease recurrence and 461 (21%) were dead from UTUC. • The 5-year RFS and CSS estimates were 71.5% and 74.2%, respectively, for Caucasian patients compared with 68.8% and 75.4%, respectively, for Japanese patients. • On univariable Cox regression analyses, ethnicity was not significantly associated with either RFS (P= 0.231) or CSS (P= 0.752). • On multivariable Cox regression analyses that adjusted for the effects of age, gender, surgical type, T stage, grade, tumour architecture, presence of concomitant carcinoma in situ, lymphovascular invasion, tumour necrosis, and lymph node status, ethnicity was not associated with either RFS (hazard ratio [HR] 1.1; P= 0.447) or CSS (HR 1.0; P= 0.908). CONCLUSIONS • There were major differences in the clinico-pathological characteristics of Caucasian and Japanese patients. • However, RFS and CSS probabilities were not affected by ethnicity and race was not an independent predictor of either recurrence or cancer-related death.

Original languageEnglish (US)
Pages (from-to)E304-E309
JournalBJU international
Volume108
Issue number8 B
DOIs
StatePublished - Oct 2011

Keywords

  • nephroureterectomy
  • prognosis
  • race
  • recurrence
  • urinary tract cancer
  • urothelial carcinoma

ASJC Scopus subject areas

  • Urology

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    Matsumoto, K., Novara, G., Gupta, A., Margulis, V., Walton, T. J., Roscigno, M., Ng, C., Kikuchi, E., Zigeuner, R., Kassouf, W., Fritsche, H. M., Ficarra, V., Martignoni, G., Tritschler, S., Rodriguez, J. C., Seitz, C., Weizer, A., Remzi, M., Raman, J. D., ... Shariat, S. F. (2011). Racial differences in the outcome of patients with urothelial carcinoma of the upper urinary tract: An international study. BJU international, 108(8 B), E304-E309. https://doi.org/10.1111/j.1464-410X.2011.10188.x