Racial differences in left atrial size: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) study

Thomas Dewland, Kirsten Bibbins-Domingo, Feng Lin, Eric Vittinghoff, Elyse Foster, Kofo O. Ogunyankin, Joao A. Lima, David R. Jacobs, Donglei Hu, Esteban G. Burchard, Gregory M. Marcus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Whites have an increased risk of atrial fibrillation (AF) compared to Blacks. The mechanism underlying this association is unknown. Left atrial (LA) size is an important AF risk factor, and studies in older adults suggest Whites have larger LA diameters. However, because AF itself causes LA dilation, LA size differences may be due to greater subclinical AF among older Whites. We therefore assessed for racial differences in LA size among young adults at low AF risk. The Coronary Artery Risk Development in Young Adults (CARDIA) study enrolled White and Black participants between 18 and 30 years of age. LA diameter was measured in a subset of participants using echocardiography at Year 5 (n = 4,201) and Year 25 (n = 3,373) of follow up. LA volume was also assessed at Year 5 (n = 2,489). Multivariate linear regression models were used to determine the adjusted association between race and LA size. In unadjusted analyses, mean LA diameter was significantly larger among Blacks compared to Whites both at Year 5 (35.5 ± 4.8 mm versus 35.1 ± 4.5 mm, p = 0.01) and Year 25 (37.4 ± 5.1 mm versus 36.8 ± 4.9 mm, p = 0.002). After adjusting for demographics, comorbidities, and echocardiographic parameters, Whites demonstrated an increased LA diameter (0.7 mm larger at Year 5, 95% CI 0.3-1.1, p

Original languageEnglish (US)
Article numbere0151559
JournalPLoS One
Volume11
Issue number3
DOIs
StatePublished - Mar 1 2016

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coronary vessels
young adults
Atrial Fibrillation
Young Adult
Coronary Vessels
Linear Models
Echocardiography
Linear regression
echocardiography
Comorbidity
Dilatation
risk factors
demographic statistics
Demography
atrial fibrillation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Dewland, T., Bibbins-Domingo, K., Lin, F., Vittinghoff, E., Foster, E., Ogunyankin, K. O., ... Marcus, G. M. (2016). Racial differences in left atrial size: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) study. PLoS One, 11(3), [e0151559]. https://doi.org/10.1371/journal.pone.0151559

Racial differences in left atrial size : Results from the Coronary Artery Risk Development in Young Adults (CARDIA) study. / Dewland, Thomas; Bibbins-Domingo, Kirsten; Lin, Feng; Vittinghoff, Eric; Foster, Elyse; Ogunyankin, Kofo O.; Lima, Joao A.; Jacobs, David R.; Hu, Donglei; Burchard, Esteban G.; Marcus, Gregory M.

In: PLoS One, Vol. 11, No. 3, e0151559, 01.03.2016.

Research output: Contribution to journalArticle

Dewland, T, Bibbins-Domingo, K, Lin, F, Vittinghoff, E, Foster, E, Ogunyankin, KO, Lima, JA, Jacobs, DR, Hu, D, Burchard, EG & Marcus, GM 2016, 'Racial differences in left atrial size: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) study', PLoS One, vol. 11, no. 3, e0151559. https://doi.org/10.1371/journal.pone.0151559
Dewland, Thomas ; Bibbins-Domingo, Kirsten ; Lin, Feng ; Vittinghoff, Eric ; Foster, Elyse ; Ogunyankin, Kofo O. ; Lima, Joao A. ; Jacobs, David R. ; Hu, Donglei ; Burchard, Esteban G. ; Marcus, Gregory M. / Racial differences in left atrial size : Results from the Coronary Artery Risk Development in Young Adults (CARDIA) study. In: PLoS One. 2016 ; Vol. 11, No. 3.
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