Rab GTPases implicated in inherited and acquired disorders

Shreya Mitra, Kwai W. Cheng, Gordon Mills

Research output: Contribution to journalReview article

68 Citations (Scopus)

Abstract

The endocytotic machinery imports, transports and exports receptors and associated molecules between the plasma membrane and various cytoplasmic chambers resulting in selective recycling, degradation, or secretion of molecules and signaling complexes. Trafficking of receptors, growth factors, nutrients, cytokines, integrins as well as pathogens dictates the kinetics and magnitude of signal transduction cascades. Understandably, alterations in the 'fate' of such cargo complexes have profound physiologic and pathophysiologic implications. Rab GTPases regulate endocytosis by decorating intracellular vesicles and targeting these vesicles along with their cargoes to appropriate subcellular compartments. In the last decade, the number of genetic diseases driven by germline mutations in Rab GTPases or their interacting proteins [1-3], has increased and there is growing evidence of aberrant Rab GTPase function in acquired pathophysiologies such as immune deficiency, infection, obesity, diabetes and cancer.

Original languageEnglish (US)
Pages (from-to)57-68
Number of pages12
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Fingerprint

rab GTP-Binding Proteins
Inborn Genetic Diseases
Growth Factor Receptors
Germ-Line Mutation
Recycling
Endocytosis
Integrins
Signal Transduction
Obesity
Cell Membrane
Cytokines
Food
Infection
Neoplasms
Proteins

Keywords

  • Cancer
  • Endocytosis
  • GLUT4
  • Rab GTPases
  • Rab25
  • Vesicular trafficking

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Rab GTPases implicated in inherited and acquired disorders. / Mitra, Shreya; Cheng, Kwai W.; Mills, Gordon.

In: Seminars in Cell and Developmental Biology, Vol. 22, No. 1, 01.01.2011, p. 57-68.

Research output: Contribution to journalReview article

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