Rab GTPases implicated in inherited and acquired disorders

Shreya Mitra, Kwai W. Cheng, Gordon B. Mills

    Research output: Contribution to journalReview article

    68 Scopus citations

    Abstract

    The endocytotic machinery imports, transports and exports receptors and associated molecules between the plasma membrane and various cytoplasmic chambers resulting in selective recycling, degradation, or secretion of molecules and signaling complexes. Trafficking of receptors, growth factors, nutrients, cytokines, integrins as well as pathogens dictates the kinetics and magnitude of signal transduction cascades. Understandably, alterations in the 'fate' of such cargo complexes have profound physiologic and pathophysiologic implications. Rab GTPases regulate endocytosis by decorating intracellular vesicles and targeting these vesicles along with their cargoes to appropriate subcellular compartments. In the last decade, the number of genetic diseases driven by germline mutations in Rab GTPases or their interacting proteins [1-3], has increased and there is growing evidence of aberrant Rab GTPase function in acquired pathophysiologies such as immune deficiency, infection, obesity, diabetes and cancer.

    Original languageEnglish (US)
    Pages (from-to)57-68
    Number of pages12
    JournalSeminars in Cell and Developmental Biology
    Volume22
    Issue number1
    DOIs
    StatePublished - Feb 2011

    Keywords

    • Cancer
    • Endocytosis
    • GLUT4
    • Rab GTPases
    • Rab25
    • Vesicular trafficking

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

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