Quantitative trait locus (QTL) mapping in mice

Abraham A. Palmer, Tamara Phillips

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)

Abstract

Complex traits, such as the human disease alcoholism, are influenced by multiple genetic and environmental factors. Animals can be used to model certain components of this disease. However, even the apparently simplified traits modeled in animals are found to be under the influence of multiple genes, each of relatively small effect. Thus, the distributions of these traits in genetically heterogeneous populations tend to be continuous, rather than displaying simple Mendelian inheritance patterns. The genomic loci that influence the quantitative variability in these traits are termed quantitative trait loci (QTL).*The identification of the genes influencing such quantitative traits can be approached using QTL mapping methods that were originally developed by plant geneticists (see Lynch and Walsh, 1998). Initial efforts may be directed at localizing an influential gene (a QTL) to a chromosome or a chromosomal segment. Additional experiments may then be performed, using stringent statistical criteria, to confirm the presence of the QTL. Finer mapping methods are then used to narrow the chromosomal region in which the QTL resides, with the ultimate goal of identifying the causative gene or regulatory element. Single gene mutants, gene expression analyses and sequence information can be used at each stage to provide evidence that a candidate gene is the QTL (Figure 1.1).

Original languageEnglish (US)
Title of host publicationMethods in Alcohol-Related Neuroscience Research
PublisherCRC Press
Pages1-30
Number of pages30
ISBN (Electronic)9781420042092
ISBN (Print)084930203X, 9780849302039
StatePublished - Jan 1 2002

Fingerprint

Quantitative Trait Loci
Genes
Animals
Inheritance Patterns
Regulator Genes
Chromosomes
Gene expression
Alcoholism
Sequence Analysis
Gene Expression
Population
Experiments

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Palmer, A. A., & Phillips, T. (2002). Quantitative trait locus (QTL) mapping in mice. In Methods in Alcohol-Related Neuroscience Research (pp. 1-30). CRC Press.

Quantitative trait locus (QTL) mapping in mice. / Palmer, Abraham A.; Phillips, Tamara.

Methods in Alcohol-Related Neuroscience Research. CRC Press, 2002. p. 1-30.

Research output: Chapter in Book/Report/Conference proceedingChapter

Palmer, AA & Phillips, T 2002, Quantitative trait locus (QTL) mapping in mice. in Methods in Alcohol-Related Neuroscience Research. CRC Press, pp. 1-30.
Palmer AA, Phillips T. Quantitative trait locus (QTL) mapping in mice. In Methods in Alcohol-Related Neuroscience Research. CRC Press. 2002. p. 1-30
Palmer, Abraham A. ; Phillips, Tamara. / Quantitative trait locus (QTL) mapping in mice. Methods in Alcohol-Related Neuroscience Research. CRC Press, 2002. pp. 1-30
@inbook{502da26aac3e4caab16286672528ae80,
title = "Quantitative trait locus (QTL) mapping in mice",
abstract = "Complex traits, such as the human disease alcoholism, are influenced by multiple genetic and environmental factors. Animals can be used to model certain components of this disease. However, even the apparently simplified traits modeled in animals are found to be under the influence of multiple genes, each of relatively small effect. Thus, the distributions of these traits in genetically heterogeneous populations tend to be continuous, rather than displaying simple Mendelian inheritance patterns. The genomic loci that influence the quantitative variability in these traits are termed quantitative trait loci (QTL).*The identification of the genes influencing such quantitative traits can be approached using QTL mapping methods that were originally developed by plant geneticists (see Lynch and Walsh, 1998). Initial efforts may be directed at localizing an influential gene (a QTL) to a chromosome or a chromosomal segment. Additional experiments may then be performed, using stringent statistical criteria, to confirm the presence of the QTL. Finer mapping methods are then used to narrow the chromosomal region in which the QTL resides, with the ultimate goal of identifying the causative gene or regulatory element. Single gene mutants, gene expression analyses and sequence information can be used at each stage to provide evidence that a candidate gene is the QTL (Figure 1.1).",
author = "Palmer, {Abraham A.} and Tamara Phillips",
year = "2002",
month = "1",
day = "1",
language = "English (US)",
isbn = "084930203X",
pages = "1--30",
booktitle = "Methods in Alcohol-Related Neuroscience Research",
publisher = "CRC Press",

}

TY - CHAP

T1 - Quantitative trait locus (QTL) mapping in mice

AU - Palmer, Abraham A.

AU - Phillips, Tamara

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Complex traits, such as the human disease alcoholism, are influenced by multiple genetic and environmental factors. Animals can be used to model certain components of this disease. However, even the apparently simplified traits modeled in animals are found to be under the influence of multiple genes, each of relatively small effect. Thus, the distributions of these traits in genetically heterogeneous populations tend to be continuous, rather than displaying simple Mendelian inheritance patterns. The genomic loci that influence the quantitative variability in these traits are termed quantitative trait loci (QTL).*The identification of the genes influencing such quantitative traits can be approached using QTL mapping methods that were originally developed by plant geneticists (see Lynch and Walsh, 1998). Initial efforts may be directed at localizing an influential gene (a QTL) to a chromosome or a chromosomal segment. Additional experiments may then be performed, using stringent statistical criteria, to confirm the presence of the QTL. Finer mapping methods are then used to narrow the chromosomal region in which the QTL resides, with the ultimate goal of identifying the causative gene or regulatory element. Single gene mutants, gene expression analyses and sequence information can be used at each stage to provide evidence that a candidate gene is the QTL (Figure 1.1).

AB - Complex traits, such as the human disease alcoholism, are influenced by multiple genetic and environmental factors. Animals can be used to model certain components of this disease. However, even the apparently simplified traits modeled in animals are found to be under the influence of multiple genes, each of relatively small effect. Thus, the distributions of these traits in genetically heterogeneous populations tend to be continuous, rather than displaying simple Mendelian inheritance patterns. The genomic loci that influence the quantitative variability in these traits are termed quantitative trait loci (QTL).*The identification of the genes influencing such quantitative traits can be approached using QTL mapping methods that were originally developed by plant geneticists (see Lynch and Walsh, 1998). Initial efforts may be directed at localizing an influential gene (a QTL) to a chromosome or a chromosomal segment. Additional experiments may then be performed, using stringent statistical criteria, to confirm the presence of the QTL. Finer mapping methods are then used to narrow the chromosomal region in which the QTL resides, with the ultimate goal of identifying the causative gene or regulatory element. Single gene mutants, gene expression analyses and sequence information can be used at each stage to provide evidence that a candidate gene is the QTL (Figure 1.1).

UR - http://www.scopus.com/inward/record.url?scp=0003304633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0003304633&partnerID=8YFLogxK

M3 - Chapter

SN - 084930203X

SN - 9780849302039

SP - 1

EP - 30

BT - Methods in Alcohol-Related Neuroscience Research

PB - CRC Press

ER -