Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition

B. Boyer, R. Odessey

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The potential for branched-chain 2-oxo acid dehydrogenase complex (BCOADC) activity to be controlled by feedback inhibition was investigated by calculating the Elasticity Coefficients for several feedback inhibitors. We suggest that feedback inhibition is a quantitatively important regulatory mechanism by which branched-chain 2-oxo acid dehydrogenase activity is regulated. The potential for control of enzyme activity is greater for NADH than for the acyl-CoA products, and suggests that factors that alter the redox potential may physiologically regulate BCOADC activity through a feedback inhibitory mechanism in vivo. Local pH may also be an important regulatory control factor.

Original languageEnglish (US)
Pages (from-to)523-528
Number of pages6
JournalBiochemical Journal
Volume271
Issue number2
DOIs
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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