Qualitative real-time cross-sectional echocardiographic imaging of the human fetus during the second half of pregnancy

L. W. Lange, David Sahn, H. D. Allen, S. J. Goldberg, C. Anderson, H. Giles

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

In this study, we used high-resolution echocardiographic systems to investigate how early in pregnancy normal fetus cardiac anatomy could be noninvasively evaluated. Over a 2-year period, 84 of 88 fetuses were successfully imaged (27 were studied serially). Postnatal images of 73 were obtained during the newborn period. Estimated fetal age varied at initial examination from 19-41 weeks (mean 31 ± 0.5 weeks [± SEM]) of pregnancy. Estimated fetal weight using an ultrasound algorithm varied from 500-3100 g (mean 1580 ± 80 g [± SEM]). To evaluate fetal cardiac anatomy, we reproduced commonly used cross-sectional views of the heart. The four-chamber and the short-axis great artery views have been most successful for cardiac evaluation in the fetus. These views could be obtained in 96% and 95% of the patients, respectively. With these views, cardiac chamber and valve structures, as well as two great arteries, could be imaged in detail. The ascending and descending aorta, as well as the aortic arch and vessels to the arms and head, were visualized in 87% of examinations, and the inferior and superior venae cavae were visualized in 76%. In two of three RH fetuses, changes in cardiac chambers compatible with hydrops fetalis were demonstrated. We examined all fetuses after birth and verified clinically (or noninvasively) that no cardiax malformations were present. It appears, however, that the diagnosis of major congenital heart defects should be possible before birth.

Original languageEnglish (US)
Pages (from-to)799-806
Number of pages8
JournalCirculation
Volume62
Issue number4
StatePublished - 1980
Externally publishedYes

Fingerprint

Fetus
Pregnancy
Thoracic Aorta
Anatomy
Arteries
Parturition
Hydrops Fetalis
Fetal Weight
Superior Vena Cava
Congenital Heart Defects
Heart Valves
Inferior Vena Cava
Gestational Age
Aorta
Arm
Head
Newborn Infant

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Lange, L. W., Sahn, D., Allen, H. D., Goldberg, S. J., Anderson, C., & Giles, H. (1980). Qualitative real-time cross-sectional echocardiographic imaging of the human fetus during the second half of pregnancy. Circulation, 62(4), 799-806.

Qualitative real-time cross-sectional echocardiographic imaging of the human fetus during the second half of pregnancy. / Lange, L. W.; Sahn, David; Allen, H. D.; Goldberg, S. J.; Anderson, C.; Giles, H.

In: Circulation, Vol. 62, No. 4, 1980, p. 799-806.

Research output: Contribution to journalArticle

Lange, LW, Sahn, D, Allen, HD, Goldberg, SJ, Anderson, C & Giles, H 1980, 'Qualitative real-time cross-sectional echocardiographic imaging of the human fetus during the second half of pregnancy', Circulation, vol. 62, no. 4, pp. 799-806.
Lange, L. W. ; Sahn, David ; Allen, H. D. ; Goldberg, S. J. ; Anderson, C. ; Giles, H. / Qualitative real-time cross-sectional echocardiographic imaging of the human fetus during the second half of pregnancy. In: Circulation. 1980 ; Vol. 62, No. 4. pp. 799-806.
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