Pyrazole exacerbates handling-induced convulsions in mice

J. C. Crabbe, E. R. Young, J. Janowsky, H. Rigter

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Abstract

Severity of handling-induced convulsions was reduced in mice in comparison to the scores on an initial test administered 4 days earlier. Daily injections of pyrazole, an inhibitor of alcohol dehydrogenase, prevented the reduction of convulsions in handled mice and exacerbated convulsions in mice tested for the first time after injection. The effects of pyrazole were dose-related.

Original languageEnglish (US)
Pages (from-to)605-609
Number of pages5
JournalNeuropharmacology
Volume20
Issue number6
DOIs
StatePublished - Jun 1981

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Keywords

  • convulsions
  • handling induced
  • mice
  • pyrazole
  • refractory period

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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