TY - JOUR
T1 - Pyoderma gangrenosum and pregnancy
T2 - An example of abnormal inflammation and challenging treatment
AU - Steele, R. B.
AU - Nugent, W. H.
AU - Braswell, S. F.
AU - Frisch, S.
AU - Ferrell, J.
AU - Ortega-Loayza, A. G.
N1 - Publisher Copyright:
© 2015 British Association of Dermatologists.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Pyoderma gangrenosum (PG) is a neutrophil-predominant inflammatory disease that initially presents as a sterile pustule and may progress to ulcerations. Its root cause is unknown, but the presentation is commonly associated with systemic inflammatory conditions such as inflammatory bowel disease, arthritis and haematological abnormalities. On the other hand, pregnant women show a progressive neutrophilia during gestation, which culminates in a major inflammatory event to help drive labour. Although uncommonly, PG has been associated with pregnancy, which provides an additional link to systemic inflammation as an underlying cause of PG. We reviewed documented presentations of PG in gravid and post-partum patients, and have speculated on the possible pathogenesis based on their clinical presentations. Also, we summarize the reported treatments and their outcomes in these patients.
AB - Pyoderma gangrenosum (PG) is a neutrophil-predominant inflammatory disease that initially presents as a sterile pustule and may progress to ulcerations. Its root cause is unknown, but the presentation is commonly associated with systemic inflammatory conditions such as inflammatory bowel disease, arthritis and haematological abnormalities. On the other hand, pregnant women show a progressive neutrophilia during gestation, which culminates in a major inflammatory event to help drive labour. Although uncommonly, PG has been associated with pregnancy, which provides an additional link to systemic inflammation as an underlying cause of PG. We reviewed documented presentations of PG in gravid and post-partum patients, and have speculated on the possible pathogenesis based on their clinical presentations. Also, we summarize the reported treatments and their outcomes in these patients.
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U2 - 10.1111/bjd.14230
DO - 10.1111/bjd.14230
M3 - Article
C2 - 26474193
AN - SCOPUS:84955627714
SN - 0007-0963
VL - 174
SP - 77
EP - 87
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 1
ER -