Pyoderma gangrenosum and pregnancy: An example of abnormal inflammation and challenging treatment

R. B. Steele, W. H. Nugent, S. F. Braswell, S. Frisch, J. Ferrell, Alex Ortega Loayza

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Pyoderma gangrenosum (PG) is a neutrophil-predominant inflammatory disease that initially presents as a sterile pustule and may progress to ulcerations. Its root cause is unknown, but the presentation is commonly associated with systemic inflammatory conditions such as inflammatory bowel disease, arthritis and haematological abnormalities. On the other hand, pregnant women show a progressive neutrophilia during gestation, which culminates in a major inflammatory event to help drive labour. Although uncommonly, PG has been associated with pregnancy, which provides an additional link to systemic inflammation as an underlying cause of PG. We reviewed documented presentations of PG in gravid and post-partum patients, and have speculated on the possible pathogenesis based on their clinical presentations. Also, we summarize the reported treatments and their outcomes in these patients.

Original languageEnglish (US)
Pages (from-to)77-87
Number of pages11
JournalBritish Journal of Dermatology
Volume174
Issue number1
DOIs
Publication statusPublished - Jan 1 2016
Externally publishedYes

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ASJC Scopus subject areas

  • Dermatology

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