Pyoderma gangrenosum: a review with special emphasis on Latin America literature

Milton José Max Rodríguez-Zúñiga, Michael S. Heath, João Renato Vianna Gontijo, Alex G. Ortega-Loayza

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Pyoderma gangrenosum is a neutrophilic dermatosis characterized by chronic ulcers due to an abnormal immune response. Despite the existence of diagnostic criteria, there is no gold standard for diagnosis or treatment. In Latin America, recognizing and treating pyoderma gangrenosum is even more challenging since skin and soft tissue bacterial and non-bacterial infections are common mimickers. Therefore, this review aims to characterize reported cases of pyoderma gangrenosum in this region in order to assist in the assessment and management of this condition. Brazil, Mexico, Argentina, and Chile are the countries in Latin America that have reported the largest cohort of patients with this disease. The most frequent clinical presentation is the ulcerative form and the most frequently associated conditions are inflammatory bowel diseases, inflammatory arthropaties, and hematologic malignancies. The most common treatment modalities include systemic corticosteroids and cyclosporine. Other reported treatments are methotrexate, dapsone, and cyclophosphamide. Finally, the use of biological therapy is still limited in this region.

Original languageEnglish (US)
Pages (from-to)729-743
Number of pages15
JournalAnais brasileiros de dermatologia
Volume94
Issue number6
DOIs
StatePublished - Nov 1 2019

Keywords

  • Inflammatory bowel diseases
  • Latin America
  • Pyoderma gangrenosum
  • Skin ulcer

ASJC Scopus subject areas

  • Dermatology

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