Pulse methylprednisolone in rheumatoid arthritis. A double-blind cross-over trial

Michael Liebling, E. Leib, K. McLaughlin, K. Blocka, D. E. Furst, K. Nyman, H. E. Paulus

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Ten patients with rheumatoid arthritis unresponsive to conventional therapy participated in a double-blind crossover trial in which they randomly received either a 'pulse' of 1 g of methylprednisolone or placebo, intravenously, once a month for 6 months. Both the drug-first and placebo-first groups had the same mean American Rheumatism Association functional classification, 2.5. During the study patients on methylprednisolone 'pulses', compared to placebo, showed significantly better mean tender-joint counts, walking times, and grip strength (p

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalAnnals of Internal Medicine
Volume94
Issue number1
StatePublished - 1981
Externally publishedYes

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Methylprednisolone
Cross-Over Studies
Rheumatoid Arthritis
Placebos
Hand Strength
Rheumatic Diseases
Walking
Joints
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liebling, M., Leib, E., McLaughlin, K., Blocka, K., Furst, D. E., Nyman, K., & Paulus, H. E. (1981). Pulse methylprednisolone in rheumatoid arthritis. A double-blind cross-over trial. Annals of Internal Medicine, 94(1), 21-26.

Pulse methylprednisolone in rheumatoid arthritis. A double-blind cross-over trial. / Liebling, Michael; Leib, E.; McLaughlin, K.; Blocka, K.; Furst, D. E.; Nyman, K.; Paulus, H. E.

In: Annals of Internal Medicine, Vol. 94, No. 1, 1981, p. 21-26.

Research output: Contribution to journalArticle

Liebling, M, Leib, E, McLaughlin, K, Blocka, K, Furst, DE, Nyman, K & Paulus, HE 1981, 'Pulse methylprednisolone in rheumatoid arthritis. A double-blind cross-over trial', Annals of Internal Medicine, vol. 94, no. 1, pp. 21-26.
Liebling M, Leib E, McLaughlin K, Blocka K, Furst DE, Nyman K et al. Pulse methylprednisolone in rheumatoid arthritis. A double-blind cross-over trial. Annals of Internal Medicine. 1981;94(1):21-26.
Liebling, Michael ; Leib, E. ; McLaughlin, K. ; Blocka, K. ; Furst, D. E. ; Nyman, K. ; Paulus, H. E. / Pulse methylprednisolone in rheumatoid arthritis. A double-blind cross-over trial. In: Annals of Internal Medicine. 1981 ; Vol. 94, No. 1. pp. 21-26.
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