Pulmonary hyalinosis in captive sugar gliders (Petaurus breviceps)

Set A. Sokol, Dalen W. Agnew, Anne Lewis, Teresa L. Southard, Andrew D. Miller

    Research output: Contribution to journalArticle

    Abstract

    Pulmonary hyalinosis is an idiopathic, typically incidental lesion of old dogs, characterized by multifocal aggregates of epithelioid and multinucleate macrophages that surround periodic acid–Schiff (PAS)-positive hyaline material in airways. Lung lesions resembling pulmonary hyalinosis were observed in 6 captive adult sugar gliders (Petaurus breviceps; 5 females and 1 male) in a retrospective review of 18 autopsied animals. Clinical signs for 3 of the sugar gliders included lethargy, tachypnea, and dyspnea. At autopsy, 5 of 6 animals had comorbid lesions that were the primary cause of death. Gross pulmonary lesions were characterized by mildly firm, discolored, vaguely nodular areas of parenchyma. Histologic examination of the lung revealed granulomatous inflammation with intracellular and extracellular amphophilic hyaline bodies within alveoli and airways. Hyaline bodies were positive for PAS and oil red O staining, blue via crystal violet staining, and displayed birefringence under polarized light, similar to findings in dogs with pulmonary hyalinosis.

    Original languageEnglish (US)
    Pages (from-to)691-695
    Number of pages5
    JournalJournal of Veterinary Diagnostic Investigation
    Volume29
    Issue number5
    DOIs
    StatePublished - Sep 1 2017

    Fingerprint

    lungs
    lesions (animal)
    Lung
    Hyalin
    Dogs
    Staining and Labeling
    Birefringence
    Gentian Violet
    Tachypnea
    gentian violet
    Lethargy
    polarized light
    dogs
    dyspnea
    cell aggregates
    Dyspnea
    Petaurus breviceps
    Cause of Death
    Autopsy
    necropsy

    Keywords

    • alveolar proteinosis
    • Alveolar-filling disorder
    • Petaurus breviceps
    • pulmonary hyalinosis
    • sugar gliders

    ASJC Scopus subject areas

    • veterinary(all)

    Cite this

    Pulmonary hyalinosis in captive sugar gliders (Petaurus breviceps). / Sokol, Set A.; Agnew, Dalen W.; Lewis, Anne; Southard, Teresa L.; Miller, Andrew D.

    In: Journal of Veterinary Diagnostic Investigation, Vol. 29, No. 5, 01.09.2017, p. 691-695.

    Research output: Contribution to journalArticle

    Sokol, Set A. ; Agnew, Dalen W. ; Lewis, Anne ; Southard, Teresa L. ; Miller, Andrew D. / Pulmonary hyalinosis in captive sugar gliders (Petaurus breviceps). In: Journal of Veterinary Diagnostic Investigation. 2017 ; Vol. 29, No. 5. pp. 691-695.
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