Pulmonary chemoreflex and phrenic sympathetic efferents

Agnieszka Balkowiec, Pawł Szulxzyk

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The pulmonary chemoreflex components such as reactions of phrenic sympathetic neuron (PhSN) activity, phrenic nerve activity, heart rate and blood pressure were tested in chloralose-anesthetized, paralyzed cats. 10 μg to 160 μg phenylbiguanide (PBG) in 0.9% NaCl was injected into the pulmonary circulation. PBG injected into the right atrium (in 11 of 19 experiments) and into the pulmonary artery (in 5 of 8 experiments), evoked short-latency (1-1.4 sec) dose-dependent increase in PhSN activity accompanied by increase in blood pressure, and followed by decrease in these two variables. In all experiments, activity of the phrenic nerve was depressed, and bradycardia occurred after PBG injection. All responses to PBG injection into the pulmonary artery were abolished following bilateral vagotomy. In the same procedure related to the right atrium after vagotomy, the increases in PhSN activity and blood pressure were also abolished, although a decrease in heart rate, PhSN activity and in the amplitude of phrenic nerve discharges together with an increase in their frequency persisted. Our results suggest that short-latency increase in PhSN activity is a component of pulmonary chemoreflex.

Original languageEnglish (US)
Pages (from-to)151-162
Number of pages12
JournalRespiration Physiology
Volume94
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Diaphragm
Phrenic Nerve
Neurons
Lung
Vagotomy
Blood Pressure
Heart Atria
Pulmonary Artery
Heart Rate
Chloralose
Injections
Pulmonary Circulation
Bradycardia
Cats
phenyl biguanide

Keywords

  • Mammals, cat
  • Nerve afferent, pulmonary C-fibers
  • Neurons, phrenic sympathetic
  • Pharmacological agents, phenylbiguanide

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Pulmonary chemoreflex and phrenic sympathetic efferents. / Balkowiec, Agnieszka; Szulxzyk, Pawł.

In: Respiration Physiology, Vol. 94, No. 2, 1993, p. 151-162.

Research output: Contribution to journalArticle

Balkowiec, Agnieszka ; Szulxzyk, Pawł. / Pulmonary chemoreflex and phrenic sympathetic efferents. In: Respiration Physiology. 1993 ; Vol. 94, No. 2. pp. 151-162.
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