TY - JOUR
T1 - Psychomotor Stimulant Addiction
T2 - A Neural Systems Perspective
AU - Everitt, Barry J.
AU - Wolf, Marina E.
PY - 2002/5/1
Y1 - 2002/5/1
N2 - There has been recent, substantial progress in understanding psychomotor stimulant, especially cocaine, addiction on two fronts: (1) characterization of the molecular basis of neuroadaptations induced by drugs of abuse and (2) identification of limbic cortical-ventral striatopallidal systems that underlie associative influences on cocaine-seeking behavior and relapse. A future challenge is to determine how particular neuroadaptations lead to plasticity in these systems, whether such changes are reversible, and how pharmacological treatments may be used to modify these processes and thereby reduce compulsive drug seeking and the propensity for relapse in human addicts.
AB - There has been recent, substantial progress in understanding psychomotor stimulant, especially cocaine, addiction on two fronts: (1) characterization of the molecular basis of neuroadaptations induced by drugs of abuse and (2) identification of limbic cortical-ventral striatopallidal systems that underlie associative influences on cocaine-seeking behavior and relapse. A future challenge is to determine how particular neuroadaptations lead to plasticity in these systems, whether such changes are reversible, and how pharmacological treatments may be used to modify these processes and thereby reduce compulsive drug seeking and the propensity for relapse in human addicts.
UR - http://www.scopus.com/inward/record.url?scp=0036584948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036584948&partnerID=8YFLogxK
U2 - 10.1523/jneurosci.22-09-03312.2002
DO - 10.1523/jneurosci.22-09-03312.2002
M3 - Short survey
C2 - 11978805
AN - SCOPUS:0036584948
SN - 0270-6474
VL - 22
SP - 3312
EP - 3320
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 9
ER -