Proximity as a factor in the innervation of host brain regions by retinal transplants

J. D. Radel, Mark Hankin, R. D. Lund

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Embryonic mouse retinae transplanted to a variety of locations within the rostral midbrain of neonatal rats exhibit selective innervation of host visual nuclei when studied at maturity. Some of these nuclei (superior colliculus, nucleus of the optic tract, dorsal terminal nucleus) usually receive extensive transplant projections, others are innervated partially (dorsal division of the lateral geniculate nucleus, olivary pretectal nucleus, medial terminal nucleus), while a few (ventral division of the lateral geniculate nucleus, suprachiasmatic nucleus, intergeniculate leaflet) are not innervated at all. The selectivity of this innervation is largely independent of the transplant's position within the rostral brainstem, while the density of innervation of individual nuclei depends in part upon the proximity of the transplant to the nucleus and upon whether the host retinal projection to that nucleus is present or absent. These findings provide a foundation for further studies of the behavioral capabilities of retinal transplants, for developmental studies of factors responsible for the establishment of normal neural projections, and for examination of the immunological consequences of transplantation.

Original languageEnglish (US)
Pages (from-to)211-229
Number of pages19
JournalJournal of Comparative Neurology
Volume300
Issue number2
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Geniculate Bodies
Transplants
Brain
Suprachiasmatic Nucleus
Superior Colliculi
Mesencephalon
Brain Stem
Retina
Transplantation
Pretectal Region

Keywords

  • neural transplantation
  • rat
  • specificity
  • visual system

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Proximity as a factor in the innervation of host brain regions by retinal transplants. / Radel, J. D.; Hankin, Mark; Lund, R. D.

In: Journal of Comparative Neurology, Vol. 300, No. 2, 01.01.1990, p. 211-229.

Research output: Contribution to journalArticle

@article{f2bf1f4929d8471181ee3857d929d2a5,
title = "Proximity as a factor in the innervation of host brain regions by retinal transplants",
abstract = "Embryonic mouse retinae transplanted to a variety of locations within the rostral midbrain of neonatal rats exhibit selective innervation of host visual nuclei when studied at maturity. Some of these nuclei (superior colliculus, nucleus of the optic tract, dorsal terminal nucleus) usually receive extensive transplant projections, others are innervated partially (dorsal division of the lateral geniculate nucleus, olivary pretectal nucleus, medial terminal nucleus), while a few (ventral division of the lateral geniculate nucleus, suprachiasmatic nucleus, intergeniculate leaflet) are not innervated at all. The selectivity of this innervation is largely independent of the transplant's position within the rostral brainstem, while the density of innervation of individual nuclei depends in part upon the proximity of the transplant to the nucleus and upon whether the host retinal projection to that nucleus is present or absent. These findings provide a foundation for further studies of the behavioral capabilities of retinal transplants, for developmental studies of factors responsible for the establishment of normal neural projections, and for examination of the immunological consequences of transplantation.",
keywords = "neural transplantation, rat, specificity, visual system",
author = "Radel, {J. D.} and Mark Hankin and Lund, {R. D.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1002/cne.903000206",
language = "English (US)",
volume = "300",
pages = "211--229",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Proximity as a factor in the innervation of host brain regions by retinal transplants

AU - Radel, J. D.

AU - Hankin, Mark

AU - Lund, R. D.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Embryonic mouse retinae transplanted to a variety of locations within the rostral midbrain of neonatal rats exhibit selective innervation of host visual nuclei when studied at maturity. Some of these nuclei (superior colliculus, nucleus of the optic tract, dorsal terminal nucleus) usually receive extensive transplant projections, others are innervated partially (dorsal division of the lateral geniculate nucleus, olivary pretectal nucleus, medial terminal nucleus), while a few (ventral division of the lateral geniculate nucleus, suprachiasmatic nucleus, intergeniculate leaflet) are not innervated at all. The selectivity of this innervation is largely independent of the transplant's position within the rostral brainstem, while the density of innervation of individual nuclei depends in part upon the proximity of the transplant to the nucleus and upon whether the host retinal projection to that nucleus is present or absent. These findings provide a foundation for further studies of the behavioral capabilities of retinal transplants, for developmental studies of factors responsible for the establishment of normal neural projections, and for examination of the immunological consequences of transplantation.

AB - Embryonic mouse retinae transplanted to a variety of locations within the rostral midbrain of neonatal rats exhibit selective innervation of host visual nuclei when studied at maturity. Some of these nuclei (superior colliculus, nucleus of the optic tract, dorsal terminal nucleus) usually receive extensive transplant projections, others are innervated partially (dorsal division of the lateral geniculate nucleus, olivary pretectal nucleus, medial terminal nucleus), while a few (ventral division of the lateral geniculate nucleus, suprachiasmatic nucleus, intergeniculate leaflet) are not innervated at all. The selectivity of this innervation is largely independent of the transplant's position within the rostral brainstem, while the density of innervation of individual nuclei depends in part upon the proximity of the transplant to the nucleus and upon whether the host retinal projection to that nucleus is present or absent. These findings provide a foundation for further studies of the behavioral capabilities of retinal transplants, for developmental studies of factors responsible for the establishment of normal neural projections, and for examination of the immunological consequences of transplantation.

KW - neural transplantation

KW - rat

KW - specificity

KW - visual system

UR - http://www.scopus.com/inward/record.url?scp=0025043813&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025043813&partnerID=8YFLogxK

U2 - 10.1002/cne.903000206

DO - 10.1002/cne.903000206

M3 - Article

VL - 300

SP - 211

EP - 229

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 2

ER -