Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference

Christopher Cunningham, Christina M. Gremel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Neurobiological mechanisms underlying rewarding and aversive effects of drugs are often studied by examining effects of various pretreatments on acquisition of conditioned place preference (CPP) or conditioned place aversion (CPA). However, few studies have looked at effects of pretreatment with the same drug used during conditioning. Such studies might offer insight into agonist actions on conditioning while also mimicking real world contingencies experienced by drug users. Previous work from our laboratory, which showed that same drug pre-exposure interfered with acquisition of ethanol CPA but not CPP, was limited by the use of only one pre-treatment time interval (65 min). Thus, the present studies were designed to study other intervals (- 5, - 15, - 30). Pretreatment of DBA/2J mice with ethanol (2 g/kg) reduced the activity response normally evoked by the conditioning dose (2 g/kg) at all pretreatment times, but acquisition of CPP was disrupted only by pretreatment at - 5 min. The overall pattern of findings suggests that ethanol's early pharmacological effects interfered with learning the association between the conditioned stimulus (CS) and ethanol 5 min later. Thus, one would expect ethanol agonists, when administered in close proximity to CS-ethanol pairings, to interfere with control of ethanol seeking by that CS.

Original languageEnglish (US)
Pages (from-to)612-619
Number of pages8
JournalPharmacology Biochemistry and Behavior
Volume85
Issue number3
DOIs
StatePublished - Nov 2006

Fingerprint

Ethanol
Pharmaceutical Preparations
Association Learning
Inbred DBA Mouse
Drug Users
Pharmacology
Conditioning (Psychology)

Keywords

  • Conditioned place preference
  • DBA/2J mice
  • Ethanol
  • Ethanol agonist
  • Learning deficit
  • Locomotor activity
  • Reward

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference. / Cunningham, Christopher; Gremel, Christina M.

In: Pharmacology Biochemistry and Behavior, Vol. 85, No. 3, 11.2006, p. 612-619.

Research output: Contribution to journalArticle

@article{144dc14b1f274f7691c0c0747538be57,
title = "Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference",
abstract = "Neurobiological mechanisms underlying rewarding and aversive effects of drugs are often studied by examining effects of various pretreatments on acquisition of conditioned place preference (CPP) or conditioned place aversion (CPA). However, few studies have looked at effects of pretreatment with the same drug used during conditioning. Such studies might offer insight into agonist actions on conditioning while also mimicking real world contingencies experienced by drug users. Previous work from our laboratory, which showed that same drug pre-exposure interfered with acquisition of ethanol CPA but not CPP, was limited by the use of only one pre-treatment time interval (65 min). Thus, the present studies were designed to study other intervals (- 5, - 15, - 30). Pretreatment of DBA/2J mice with ethanol (2 g/kg) reduced the activity response normally evoked by the conditioning dose (2 g/kg) at all pretreatment times, but acquisition of CPP was disrupted only by pretreatment at - 5 min. The overall pattern of findings suggests that ethanol's early pharmacological effects interfered with learning the association between the conditioned stimulus (CS) and ethanol 5 min later. Thus, one would expect ethanol agonists, when administered in close proximity to CS-ethanol pairings, to interfere with control of ethanol seeking by that CS.",
keywords = "Conditioned place preference, DBA/2J mice, Ethanol, Ethanol agonist, Learning deficit, Locomotor activity, Reward",
author = "Christopher Cunningham and Gremel, {Christina M.}",
year = "2006",
month = "11",
doi = "10.1016/j.pbb.2006.10.016",
language = "English (US)",
volume = "85",
pages = "612--619",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference

AU - Cunningham, Christopher

AU - Gremel, Christina M.

PY - 2006/11

Y1 - 2006/11

N2 - Neurobiological mechanisms underlying rewarding and aversive effects of drugs are often studied by examining effects of various pretreatments on acquisition of conditioned place preference (CPP) or conditioned place aversion (CPA). However, few studies have looked at effects of pretreatment with the same drug used during conditioning. Such studies might offer insight into agonist actions on conditioning while also mimicking real world contingencies experienced by drug users. Previous work from our laboratory, which showed that same drug pre-exposure interfered with acquisition of ethanol CPA but not CPP, was limited by the use of only one pre-treatment time interval (65 min). Thus, the present studies were designed to study other intervals (- 5, - 15, - 30). Pretreatment of DBA/2J mice with ethanol (2 g/kg) reduced the activity response normally evoked by the conditioning dose (2 g/kg) at all pretreatment times, but acquisition of CPP was disrupted only by pretreatment at - 5 min. The overall pattern of findings suggests that ethanol's early pharmacological effects interfered with learning the association between the conditioned stimulus (CS) and ethanol 5 min later. Thus, one would expect ethanol agonists, when administered in close proximity to CS-ethanol pairings, to interfere with control of ethanol seeking by that CS.

AB - Neurobiological mechanisms underlying rewarding and aversive effects of drugs are often studied by examining effects of various pretreatments on acquisition of conditioned place preference (CPP) or conditioned place aversion (CPA). However, few studies have looked at effects of pretreatment with the same drug used during conditioning. Such studies might offer insight into agonist actions on conditioning while also mimicking real world contingencies experienced by drug users. Previous work from our laboratory, which showed that same drug pre-exposure interfered with acquisition of ethanol CPA but not CPP, was limited by the use of only one pre-treatment time interval (65 min). Thus, the present studies were designed to study other intervals (- 5, - 15, - 30). Pretreatment of DBA/2J mice with ethanol (2 g/kg) reduced the activity response normally evoked by the conditioning dose (2 g/kg) at all pretreatment times, but acquisition of CPP was disrupted only by pretreatment at - 5 min. The overall pattern of findings suggests that ethanol's early pharmacological effects interfered with learning the association between the conditioned stimulus (CS) and ethanol 5 min later. Thus, one would expect ethanol agonists, when administered in close proximity to CS-ethanol pairings, to interfere with control of ethanol seeking by that CS.

KW - Conditioned place preference

KW - DBA/2J mice

KW - Ethanol

KW - Ethanol agonist

KW - Learning deficit

KW - Locomotor activity

KW - Reward

UR - http://www.scopus.com/inward/record.url?scp=33846239444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846239444&partnerID=8YFLogxK

U2 - 10.1016/j.pbb.2006.10.016

DO - 10.1016/j.pbb.2006.10.016

M3 - Article

C2 - 17141849

AN - SCOPUS:33846239444

VL - 85

SP - 612

EP - 619

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -