Proton Beam Irradiation And Hyperthermia: Effects On Experimental Choroidal Melanoma

Klaus G. Riedel, Daniel M. Albert, Paul P. Svitra, Johanna M. Seddon, Evangelos S. Gragoudas, Andreas M. Koehler, D. Jackson Coleman, Joan Torpey, Frederic L. Lizzi, Jack Driller

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Abstract

Ultrasonically induced hyperthermia (4.75 MHz) and proton irradiation (160 meV) were evaluated alone and combined to treat experimental choroidal melanoma in 58 rabbit eyes. Threshold tumoricidal doses were established for each modality. Therapy was performed combining subthreshold doses of heat and radiation. Focused ultrasonic energy via an external beam was found to deliver well-localized heat to an intraocular tumor. Ectopic temperature elevations due to soft-tissuebone interfaces were alleviated by modifying beam alignment. The results indicate that hyperthermia (43 °C for one hour) potentiated the tumoricidal effects of radiation, while sparing normal ocular structures. Therefore, we believe that experimental hyperthermia is suitable as an adjuvant treatment modality. This shows that ultrasound hyperthermia has the potential to increase the efficacy of proton irradiation by lowering radiation doses and thus decreasing posttreatment ocular morbidity in human intraocular malignancies.

Original languageEnglish (US)
Pages (from-to)1862-1869
Number of pages8
JournalArchives of ophthalmology
Volume103
Issue number12
DOIs
StatePublished - Dec 1985

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Riedel, K. G., Albert, D. M., Svitra, P. P., Seddon, J. M., Gragoudas, E. S., Koehler, A. M., Coleman, D. J., Torpey, J., Lizzi, F. L., & Driller, J. (1985). Proton Beam Irradiation And Hyperthermia: Effects On Experimental Choroidal Melanoma. Archives of ophthalmology, 103(12), 1862-1869. https://doi.org/10.1001/archopht.1985.01050120096028