Proteomic analysis of cervical vaginal fluid proteins among women in recurrent preterm labor

Jamie Lo, Ashok P. Reddy, Phillip Wilmarth, Victoria Roberts, Amanda Kinhnarath, Janice Snyder, Monica P. Rincon, Michael G. Gravett, Srinivasa R. Nagalla, Leonardo Pereira

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Proteomic analysis of four cervical-vaginal fluid (CVF) proteins to identify biomarkers of recurrent preterm birth (rPTB) in at-risk women prior to onset of preterm labor. Methods: Nested case control study from 2007 to 2011 of women with prior spontaneous preterm birth(s) (PTB) who underwent serial CVF sampling. Mass spectrometry analysis was used and ELISA analysis was performed to validate candidates. Results: 108 patients were enrolled and 10 cases and 20 gestational age matched controls were analyzed after exclusions. Of 748 CVF proteins identified, 72 had statistically significant (p

Original languageEnglish (US)
Pages (from-to)1183-1188
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume27
Issue number12
DOIs
StatePublished - 2014

Fingerprint

Premature Obstetric Labor
Premature Birth
Proteomics
Gestational Age
Case-Control Studies
Mass Spectrometry
Proteins
Biomarkers
Enzyme-Linked Immunosorbent Assay

Keywords

  • Cervical vaginal fluid
  • Proteins
  • Proteomics
  • Recurrent preterm birth

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Proteomic analysis of cervical vaginal fluid proteins among women in recurrent preterm labor. / Lo, Jamie; Reddy, Ashok P.; Wilmarth, Phillip; Roberts, Victoria; Kinhnarath, Amanda; Snyder, Janice; Rincon, Monica P.; Gravett, Michael G.; Nagalla, Srinivasa R.; Pereira, Leonardo.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 27, No. 12, 2014, p. 1183-1188.

Research output: Contribution to journalArticle

Lo, Jamie ; Reddy, Ashok P. ; Wilmarth, Phillip ; Roberts, Victoria ; Kinhnarath, Amanda ; Snyder, Janice ; Rincon, Monica P. ; Gravett, Michael G. ; Nagalla, Srinivasa R. ; Pereira, Leonardo. / Proteomic analysis of cervical vaginal fluid proteins among women in recurrent preterm labor. In: Journal of Maternal-Fetal and Neonatal Medicine. 2014 ; Vol. 27, No. 12. pp. 1183-1188.
@article{825615e36eeb4393a70ee93683bd7cd4,
title = "Proteomic analysis of cervical vaginal fluid proteins among women in recurrent preterm labor",
abstract = "Objective: Proteomic analysis of four cervical-vaginal fluid (CVF) proteins to identify biomarkers of recurrent preterm birth (rPTB) in at-risk women prior to onset of preterm labor. Methods: Nested case control study from 2007 to 2011 of women with prior spontaneous preterm birth(s) (PTB) who underwent serial CVF sampling. Mass spectrometry analysis was used and ELISA analysis was performed to validate candidates. Results: 108 patients were enrolled and 10 cases and 20 gestational age matched controls were analyzed after exclusions. Of 748 CVF proteins identified, 72 had statistically significant (p",
keywords = "Cervical vaginal fluid, Proteins, Proteomics, Recurrent preterm birth",
author = "Jamie Lo and Reddy, {Ashok P.} and Phillip Wilmarth and Victoria Roberts and Amanda Kinhnarath and Janice Snyder and Rincon, {Monica P.} and Gravett, {Michael G.} and Nagalla, {Srinivasa R.} and Leonardo Pereira",
year = "2014",
doi = "10.3109/14767058.2013.852172",
language = "English (US)",
volume = "27",
pages = "1183--1188",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "12",

}

TY - JOUR

T1 - Proteomic analysis of cervical vaginal fluid proteins among women in recurrent preterm labor

AU - Lo, Jamie

AU - Reddy, Ashok P.

AU - Wilmarth, Phillip

AU - Roberts, Victoria

AU - Kinhnarath, Amanda

AU - Snyder, Janice

AU - Rincon, Monica P.

AU - Gravett, Michael G.

AU - Nagalla, Srinivasa R.

AU - Pereira, Leonardo

PY - 2014

Y1 - 2014

N2 - Objective: Proteomic analysis of four cervical-vaginal fluid (CVF) proteins to identify biomarkers of recurrent preterm birth (rPTB) in at-risk women prior to onset of preterm labor. Methods: Nested case control study from 2007 to 2011 of women with prior spontaneous preterm birth(s) (PTB) who underwent serial CVF sampling. Mass spectrometry analysis was used and ELISA analysis was performed to validate candidates. Results: 108 patients were enrolled and 10 cases and 20 gestational age matched controls were analyzed after exclusions. Of 748 CVF proteins identified, 72 had statistically significant (p

AB - Objective: Proteomic analysis of four cervical-vaginal fluid (CVF) proteins to identify biomarkers of recurrent preterm birth (rPTB) in at-risk women prior to onset of preterm labor. Methods: Nested case control study from 2007 to 2011 of women with prior spontaneous preterm birth(s) (PTB) who underwent serial CVF sampling. Mass spectrometry analysis was used and ELISA analysis was performed to validate candidates. Results: 108 patients were enrolled and 10 cases and 20 gestational age matched controls were analyzed after exclusions. Of 748 CVF proteins identified, 72 had statistically significant (p

KW - Cervical vaginal fluid

KW - Proteins

KW - Proteomics

KW - Recurrent preterm birth

UR - http://www.scopus.com/inward/record.url?scp=84903954085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903954085&partnerID=8YFLogxK

U2 - 10.3109/14767058.2013.852172

DO - 10.3109/14767058.2013.852172

M3 - Article

C2 - 24102235

AN - SCOPUS:84903954085

VL - 27

SP - 1183

EP - 1188

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 12

ER -