TY - JOUR
T1 - Protein folding and quality control in the endoplasmic reticulum
T2 - Recent lessons from yeast and mammalian cell systems
AU - Brodsky, Jeffrey L.
AU - Skach, William R.
N1 - Funding Information:
The authors acknowledge support from grants from the National Institutes of Health ( GM75061 and DK79307 , ‘ The Pittsburgh Center for Kidney Research ’, to J.L.B., and GM53457 and DK51818 to W.R.S.) and from Cystic Fibrosis Foundation Therapeutics.
PY - 2011/8
Y1 - 2011/8
N2 - The evolution of eukaryotes was accompanied by an increased need for intracellular communication and cellular specialization. Thus, a more complex collection of secreted and membrane proteins had to be synthesized, modified, and folded. The endoplasmic reticulum (ER) thereby became equipped with devoted enzymes and associated factors that both catalyze the production of secreted proteins and remove damaged proteins. A means to modify ER function to accommodate and destroy misfolded proteins also evolved. Not surprisingly, a growing number of human diseases are linked to various facets of ER function. Each of these topics will be discussed in this article, with an emphasis on recent reports in the literature that employed diverse models.
AB - The evolution of eukaryotes was accompanied by an increased need for intracellular communication and cellular specialization. Thus, a more complex collection of secreted and membrane proteins had to be synthesized, modified, and folded. The endoplasmic reticulum (ER) thereby became equipped with devoted enzymes and associated factors that both catalyze the production of secreted proteins and remove damaged proteins. A means to modify ER function to accommodate and destroy misfolded proteins also evolved. Not surprisingly, a growing number of human diseases are linked to various facets of ER function. Each of these topics will be discussed in this article, with an emphasis on recent reports in the literature that employed diverse models.
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U2 - 10.1016/j.ceb.2011.05.004
DO - 10.1016/j.ceb.2011.05.004
M3 - Review article
C2 - 21664808
AN - SCOPUS:79960711299
SN - 0955-0674
VL - 23
SP - 464
EP - 475
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 4
ER -