Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

Jeffrey L. Brodsky, William R. Skach

    Research output: Contribution to journalReview articlepeer-review

    151 Scopus citations

    Abstract

    The evolution of eukaryotes was accompanied by an increased need for intracellular communication and cellular specialization. Thus, a more complex collection of secreted and membrane proteins had to be synthesized, modified, and folded. The endoplasmic reticulum (ER) thereby became equipped with devoted enzymes and associated factors that both catalyze the production of secreted proteins and remove damaged proteins. A means to modify ER function to accommodate and destroy misfolded proteins also evolved. Not surprisingly, a growing number of human diseases are linked to various facets of ER function. Each of these topics will be discussed in this article, with an emphasis on recent reports in the literature that employed diverse models.

    Original languageEnglish (US)
    Pages (from-to)464-475
    Number of pages12
    JournalCurrent Opinion in Cell Biology
    Volume23
    Issue number4
    DOIs
    StatePublished - Aug 2011

    ASJC Scopus subject areas

    • Cell Biology

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