Prostate cancer in the post-transplant population

Badrinath R. Konety, Ashutosh Tewari, Richard J. Howard, John Barry, Ernest E. Hodge, Rodney Taylor, Mark L. Jordan

Research output: Contribution to journalArticle

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Abstract

Objectives. We conducted a multicenter retrospective study to determine the results of treatment for prostate cancer in solid organ transplant recipients. Methods. A retrospective analysis of all patients diagnosed with prostate cancer after organ transplantation at five centers was conducted. Data were obtained by chart review and a multipoint data sheet was used to abstract the data from the patient charts. Results. Eighteen cases of prostate cancer were identified from six institutions. Most (84%) of the cancers were clinically localized at the time of diagnosis. Nine (50%) of 18 patients underwent radical prostatectomy, which was the predominant mode of treatment. Overall survival at a mean follow-up of 32 months was 66%, with a cancer specific mortality of 16%. Mortality was 13% for the 15 patients with localized disease and 33% for the 3 patients with metasiatic disease at the time of diagnosis. Conclusions. Most of the patients with prostate cancer being detected after solid organ transplantation were diagnosed with localized disease. Aggressive therapeutic intervention as in the general (nontransplant) population yields good results and should be pursued. Diligent surveillance for prostate cancer in this population using periodic digital rectal examination, serum prostate-specific antigen, and prostate needle biopsy as needed will ensure earlier cancer detection and allow for definitive therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)428-432
Number of pages5
JournalUrology
Volume52
Issue number3
DOIs
StatePublished - Sep 1998
Externally publishedYes

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Prostatic Neoplasms
Transplants
Population
Organ Transplantation
Digital Rectal Examination
Mortality
Needle Biopsy
Therapeutics
Prostate-Specific Antigen
Prostatectomy
Early Detection of Cancer
Multicenter Studies
Prostate
Neoplasms
Retrospective Studies
Survival
Serum

ASJC Scopus subject areas

  • Urology

Cite this

Konety, B. R., Tewari, A., Howard, R. J., Barry, J., Hodge, E. E., Taylor, R., & Jordan, M. L. (1998). Prostate cancer in the post-transplant population. Urology, 52(3), 428-432. https://doi.org/10.1016/S0090-4295(98)00211-8

Prostate cancer in the post-transplant population. / Konety, Badrinath R.; Tewari, Ashutosh; Howard, Richard J.; Barry, John; Hodge, Ernest E.; Taylor, Rodney; Jordan, Mark L.

In: Urology, Vol. 52, No. 3, 09.1998, p. 428-432.

Research output: Contribution to journalArticle

Konety, BR, Tewari, A, Howard, RJ, Barry, J, Hodge, EE, Taylor, R & Jordan, ML 1998, 'Prostate cancer in the post-transplant population', Urology, vol. 52, no. 3, pp. 428-432. https://doi.org/10.1016/S0090-4295(98)00211-8
Konety BR, Tewari A, Howard RJ, Barry J, Hodge EE, Taylor R et al. Prostate cancer in the post-transplant population. Urology. 1998 Sep;52(3):428-432. https://doi.org/10.1016/S0090-4295(98)00211-8
Konety, Badrinath R. ; Tewari, Ashutosh ; Howard, Richard J. ; Barry, John ; Hodge, Ernest E. ; Taylor, Rodney ; Jordan, Mark L. / Prostate cancer in the post-transplant population. In: Urology. 1998 ; Vol. 52, No. 3. pp. 428-432.
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