Projection-resolved optical coherence tomographic angiography

Research output: Contribution to journalArticle

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Abstract

Shadowgraphic projection artifacts from superficial vasculature interfere with the visualization of deeper vascular networks in optical coherence tomography angiography (OCT-A). We developed a novel algorithm to remove this artifact by resolving the ambiguity between in situ and projected flow signals. The algorithm identifies voxels with in situ flow as those where intensity-normalized decorrelation values are higher than all shallower voxels in the same axial scan line. This “projection-resolved” (PR) algorithm effectively suppressed the projection artifact on both en face and cross-sectional angiograms and enhanced depth resolution of vascular networks. In the human macula, the enhanced angiograms show three distinct vascular plexuses in the inner retina and no vessels in the outer retina. We demonstrate that PR OCT-A cleanly removes flow projection from the normally avascular outer retinal slab while preserving the density and continuity of the intermediate and deep retinal capillary plexuses.

Original languageEnglish (US)
Article number255669
Pages (from-to)816-828
Number of pages13
JournalBiomedical Optics Express
Volume7
Issue number3
DOIs
Publication statusPublished - Feb 9 2016

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Keywords

  • Image analysis
  • Image processing
  • Ophthalmology
  • Optical coherence tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

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