Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results from a 3.5-Year, Longitudinal Randomized Controlled Trial

Kun Hu, Rixt F. Riemersma-Van Der Lek, Melissa Patxot, Peng Li, Steven Shea, Frank A J L Scheer, Eus J W Van Someren

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cross-sectional studies show that activity fluctuations in healthy young adults possess robust temporal correlations that become altered with aging, and in dementia and depression. This study was designed to test whether or not within-subject changes of activity correlations (i) track the clinical progression of dementia, (ii) reflect the alterations of depression symptoms in patients with dementia, and (iii) can be manipulated by clinical interventions aimed at stabilizing circadian rhythmicity and improving sleep in dementia, namely timed bright light therapy and melatonin supplementation. We examined 144 patients with dementia (70-96 years old) who were assigned to daily treatment with bright light, bedtime melatonin, both or placebos only in a 3.5-year double-blinded randomized clinical trial. We found that activity correlations at temporal scales

Original languageEnglish (US)
Article number27742
JournalScientific Reports
Volume6
DOIs
StatePublished - Jun 13 2016

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Dementia
Randomized Controlled Trials
Exercise
Melatonin
Depression
Phototherapy
Periodicity
Young Adult
Sleep
Cross-Sectional Studies
Placebos
Light
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Progression of Dementia Assessed by Temporal Correlations of Physical Activity : Results from a 3.5-Year, Longitudinal Randomized Controlled Trial. / Hu, Kun; Riemersma-Van Der Lek, Rixt F.; Patxot, Melissa; Li, Peng; Shea, Steven; Scheer, Frank A J L; Van Someren, Eus J W.

In: Scientific Reports, Vol. 6, 27742, 13.06.2016.

Research output: Contribution to journalArticle

Hu, Kun ; Riemersma-Van Der Lek, Rixt F. ; Patxot, Melissa ; Li, Peng ; Shea, Steven ; Scheer, Frank A J L ; Van Someren, Eus J W. / Progression of Dementia Assessed by Temporal Correlations of Physical Activity : Results from a 3.5-Year, Longitudinal Randomized Controlled Trial. In: Scientific Reports. 2016 ; Vol. 6.
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