TY - JOUR
T1 - Progression of Dementia Assessed by Temporal Correlations of Physical Activity
T2 - Results from a 3.5-Year, Longitudinal Randomized Controlled Trial
AU - Hu, Kun
AU - Riemersma-Van Der Lek, Rixt F.
AU - Patxot, Melissa
AU - Li, Peng
AU - Shea, Steven A.
AU - Scheer, Frank A.J.L.
AU - Van Someren, Eus J.W.
N1 - Funding Information:
This work was supported by NIH grants R00-HL102241, R01AG048108-01A1 and P01AG009975 to K.H.; K24-HL076446 to S.A.S.; R01-HL118601 to F.A.J.L.S.; the China Postdoctoral Council, the International Postdoctoral Exchange Fellowship 20150042 to P.L.; the Netherlands Organization for Health Research, the Hague, grants 0028-300-30 and 907-00-012, the Netherlands Organisation for Scientific Research, the Hague, grant VICI 453-07-001, Hersenstichting Nederland grant 11F04-2.47, and Internationale Stichting Alzheimer Onderzoek grant 05511 to E.J.W.V.S.
PY - 2016/6/13
Y1 - 2016/6/13
N2 - Cross-sectional studies show that activity fluctuations in healthy young adults possess robust temporal correlations that become altered with aging, and in dementia and depression. This study was designed to test whether or not within-subject changes of activity correlations (i) track the clinical progression of dementia, (ii) reflect the alterations of depression symptoms in patients with dementia, and (iii) can be manipulated by clinical interventions aimed at stabilizing circadian rhythmicity and improving sleep in dementia, namely timed bright light therapy and melatonin supplementation. We examined 144 patients with dementia (70-96 years old) who were assigned to daily treatment with bright light, bedtime melatonin, both or placebos only in a 3.5-year double-blinded randomized clinical trial. We found that activity correlations at temporal scales <∼2 hours significantly decreased over time and that light treatment attenuated the decrease by ∼73%. Moreover, the decrease of temporal activity correlations positively correlated with the degrees of cognitive decline and worsening of mood though the associations were relatively weak. These results suggest a mechanistic link between multiscale activity regulation and circadian/sleep function in dementia patients. Whether temporal activity patterns allow unobtrusive, long-term monitoring of dementia progression and mood changes is worth further investigation.
AB - Cross-sectional studies show that activity fluctuations in healthy young adults possess robust temporal correlations that become altered with aging, and in dementia and depression. This study was designed to test whether or not within-subject changes of activity correlations (i) track the clinical progression of dementia, (ii) reflect the alterations of depression symptoms in patients with dementia, and (iii) can be manipulated by clinical interventions aimed at stabilizing circadian rhythmicity and improving sleep in dementia, namely timed bright light therapy and melatonin supplementation. We examined 144 patients with dementia (70-96 years old) who were assigned to daily treatment with bright light, bedtime melatonin, both or placebos only in a 3.5-year double-blinded randomized clinical trial. We found that activity correlations at temporal scales <∼2 hours significantly decreased over time and that light treatment attenuated the decrease by ∼73%. Moreover, the decrease of temporal activity correlations positively correlated with the degrees of cognitive decline and worsening of mood though the associations were relatively weak. These results suggest a mechanistic link between multiscale activity regulation and circadian/sleep function in dementia patients. Whether temporal activity patterns allow unobtrusive, long-term monitoring of dementia progression and mood changes is worth further investigation.
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U2 - 10.1038/srep27742
DO - 10.1038/srep27742
M3 - Article
C2 - 27292543
AN - SCOPUS:84974539511
SN - 2045-2322
VL - 6
JO - Scientific Reports
JF - Scientific Reports
M1 - 27742
ER -