Progress in development of immunocontraceptive vaccines for permanent non-surgical sterilization of cats and dogs

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Each year, millions of cats and dogs are euthanized worldwide. There are insufficient resources to control shelter animals in developed countries, as well as feral cat and wild dog population levels, with current surgical sterilization techniques. Thus, population control of these animals will likely depend on the development of new non-surgical methods for cat and dog sterilization. One promising area of research is the development of contraceptive vaccines, or immunocontraceptives. In this article, previous approaches aimed at developing contraceptive vaccines will be reviewed, with a focus on those most related to sterilization of cats and dogs. There are a number of steps in reproduction that have been, or could be, targeted by the immune system, and the advantages and obstacles for inducing immunity to each of these will be discussed. Our current understanding of how these vaccines cause sterility, and our current ability to dissect these mechanisms in cats and dogs, also will be discussed.

Original languageEnglish (US)
Pages (from-to)223-227
Number of pages5
JournalReproduction in Domestic Animals
Volume47
Issue numberSUPPL.4
DOIs
StatePublished - Aug 2012
Externally publishedYes

Fingerprint

vaccine development
Cats
Vaccines
Dogs
cats
contraceptive vaccines
Contraceptive Vaccines
dogs
Population Control
Developed Countries
developed countries
Infertility
Reproduction
immune system
Immune System
Immunity
animals
immunity
vaccines
methodology

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biotechnology
  • Endocrinology

Cite this

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abstract = "Each year, millions of cats and dogs are euthanized worldwide. There are insufficient resources to control shelter animals in developed countries, as well as feral cat and wild dog population levels, with current surgical sterilization techniques. Thus, population control of these animals will likely depend on the development of new non-surgical methods for cat and dog sterilization. One promising area of research is the development of contraceptive vaccines, or immunocontraceptives. In this article, previous approaches aimed at developing contraceptive vaccines will be reviewed, with a focus on those most related to sterilization of cats and dogs. There are a number of steps in reproduction that have been, or could be, targeted by the immune system, and the advantages and obstacles for inducing immunity to each of these will be discussed. Our current understanding of how these vaccines cause sterility, and our current ability to dissect these mechanisms in cats and dogs, also will be discussed.",
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