Abstract
Each year, millions of cats and dogs are euthanized worldwide. There are insufficient resources to control shelter animals in developed countries, as well as feral cat and wild dog population levels, with current surgical sterilization techniques. Thus, population control of these animals will likely depend on the development of new non-surgical methods for cat and dog sterilization. One promising area of research is the development of contraceptive vaccines, or immunocontraceptives. In this article, previous approaches aimed at developing contraceptive vaccines will be reviewed, with a focus on those most related to sterilization of cats and dogs. There are a number of steps in reproduction that have been, or could be, targeted by the immune system, and the advantages and obstacles for inducing immunity to each of these will be discussed. Our current understanding of how these vaccines cause sterility, and our current ability to dissect these mechanisms in cats and dogs, also will be discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 223-227 |
| Number of pages | 5 |
| Journal | Reproduction in Domestic Animals |
| Volume | 47 |
| Issue number | SUPPL.4 |
| DOIs | |
| State | Published - Aug 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Animal Science and Zoology
- Biotechnology
- Endocrinology
Cite this
Progress in development of immunocontraceptive vaccines for permanent non-surgical sterilization of cats and dogs. / Munks, Michael.
In: Reproduction in Domestic Animals, Vol. 47, No. SUPPL.4, 08.2012, p. 223-227.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Progress in development of immunocontraceptive vaccines for permanent non-surgical sterilization of cats and dogs
AU - Munks, Michael
PY - 2012/8
Y1 - 2012/8
N2 - Each year, millions of cats and dogs are euthanized worldwide. There are insufficient resources to control shelter animals in developed countries, as well as feral cat and wild dog population levels, with current surgical sterilization techniques. Thus, population control of these animals will likely depend on the development of new non-surgical methods for cat and dog sterilization. One promising area of research is the development of contraceptive vaccines, or immunocontraceptives. In this article, previous approaches aimed at developing contraceptive vaccines will be reviewed, with a focus on those most related to sterilization of cats and dogs. There are a number of steps in reproduction that have been, or could be, targeted by the immune system, and the advantages and obstacles for inducing immunity to each of these will be discussed. Our current understanding of how these vaccines cause sterility, and our current ability to dissect these mechanisms in cats and dogs, also will be discussed.
AB - Each year, millions of cats and dogs are euthanized worldwide. There are insufficient resources to control shelter animals in developed countries, as well as feral cat and wild dog population levels, with current surgical sterilization techniques. Thus, population control of these animals will likely depend on the development of new non-surgical methods for cat and dog sterilization. One promising area of research is the development of contraceptive vaccines, or immunocontraceptives. In this article, previous approaches aimed at developing contraceptive vaccines will be reviewed, with a focus on those most related to sterilization of cats and dogs. There are a number of steps in reproduction that have been, or could be, targeted by the immune system, and the advantages and obstacles for inducing immunity to each of these will be discussed. Our current understanding of how these vaccines cause sterility, and our current ability to dissect these mechanisms in cats and dogs, also will be discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=84864303602&partnerID=8YFLogxK
U2 - 10.1111/j.1439-0531.2012.02079.x
DO - 10.1111/j.1439-0531.2012.02079.x
M3 - Article
C2 - 22827374
AN - SCOPUS:84864303602
VL - 47
SP - 223
EP - 227
JO - Reproduction in Domestic Animals
JF - Reproduction in Domestic Animals
SN - 0936-6768
IS - SUPPL.4
ER -