Progress and challenges in therapies for AIDS in nonhuman primate models

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Efforts to develop animal models for human immunodeficiency virus type-1 (HIV-1) vaccine testing have focused on lentivirus infection of nonhuman primates. A long-term goal of this primate research is to utilize the models to understand the mechanisms of pathogenesis leading to AIDS. Because the time to disease is compressed relative to HIV infection in humans, therapeutic strategies and compounds can be tested in nonhuman primate models in a shorter time frame and under more controlled conditions than are possible in many clinical studies. Recent interventive studies in primates using antiviral drugs or passive immune globulin (IgG) have demonstrated that multiple log reductions in plasma virus can be achieved and sustained, with accompanying health benefits. Information gained about timing and dosage may be of utility in designing clinical studies. The development of reliable and predictable animal models for effective therapies and vaccines against AIDS remains a critical priority for primate research.

Original languageEnglish (US)
Pages (from-to)154-163
Number of pages10
JournalJournal of medical primatology
Volume28
Issue number4-5
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Antibodies
  • Antiviral drugs
  • HIVIG
  • IgG
  • Passive immunotherapy
  • SIVIG

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Fingerprint Dive into the research topics of 'Progress and challenges in therapies for AIDS in nonhuman primate models'. Together they form a unique fingerprint.

Cite this