Progress and challenges in therapies for AIDS in nonhuman primate models

    Research output: Contribution to journalArticle

    9 Scopus citations

    Abstract

    Efforts to develop animal models for human immunodeficiency virus type-1 (HIV-1) vaccine testing have focused on lentivirus infection of nonhuman primates. A long-term goal of this primate research is to utilize the models to understand the mechanisms of pathogenesis leading to AIDS. Because the time to disease is compressed relative to HIV infection in humans, therapeutic strategies and compounds can be tested in nonhuman primate models in a shorter time frame and under more controlled conditions than are possible in many clinical studies. Recent interventive studies in primates using antiviral drugs or passive immune globulin (IgG) have demonstrated that multiple log reductions in plasma virus can be achieved and sustained, with accompanying health benefits. Information gained about timing and dosage may be of utility in designing clinical studies. The development of reliable and predictable animal models for effective therapies and vaccines against AIDS remains a critical priority for primate research.

    Original languageEnglish (US)
    Pages (from-to)154-163
    Number of pages10
    JournalJournal of medical primatology
    Volume28
    Issue number4-5
    DOIs
    StatePublished - Jan 1 1999

    Keywords

    • Antibodies
    • Antiviral drugs
    • HIVIG
    • IgG
    • Passive immunotherapy
    • SIVIG

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

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