Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection

Gaëlle Breton, Nicolas Chomont, Hiroshi Takata, Rémi Fromentin, Jeffrey Ahlers, Abdelali Filali-Mouhim, Catherine Riou, Mohamed Rachid Boulassel, Jean Pierre Routy, Bader Yassine-Diab, Rafick Pierre Sékaly

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Chronic activation of T cells is a hallmark of HIV-1 infection and plays an important role in disease progression. We previously showed that the engagement of the inhibitory receptor programmed death (PD)-1 on HIV-1-specific CD4 + and CD8+ T cells leads to their functional exhaustion in vitro. However, little is known about the impact of PD-1 expression on the turnover and maturation status of T cells during the course of the disease. In this study, we show that PD-1 is upregulated on all T cell subsets, including naive, central memory, and transitional memory T cells in HIV-1-infected subjects. PD-1 is expressed at similar levels on most CD4+ T cells during the acute and the chronic phase of disease and identifies cells that have recently entered the cell cycle. In contrast, PD-1 expression is dramatically increased in CD8+ T cells during the transition from acute to chronic infection, and this is associated with reduced levels of cell proliferation. The failure to downregulate expression of PD-1 in most T cells during chronic HIV-1 infection is associated with persistent alterations in the distribution of T cell subsets and is associated with impaired responses to IL-7. Our findings identify PD-1 as a marker for aberrant distribution of T cell subsets in HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)2194-2204
Number of pages11
JournalJournal of Immunology
Volume191
Issue number5
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection'. Together they form a unique fingerprint.

Cite this