Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing

Alejandro Aballay, F. M. Ausubel

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Programmed cell death (PCD) in mammals has been implicated in several disease states including cancer, autoimmune disease, and neurodegenerative disease. In Caenorhabditis elegans, PCD is a normal component of development. We find that Salmonella typhimurium colonization of the C. elegans intestine leads to an increased level of cell death in the worm gonad, S. typhimurium-mediated germ-line cell death is not observed in C. elegans ced-3 and ced-4 mutants in which developmentally regulated cell death is blocked, and ced-3 and ced-4 mutants are hypersensitive to S. typhimurium-mediated killing. These results suggest that PCD may be involved in the C. elegans defense response to pathogen attack.

Original languageEnglish (US)
Pages (from-to)2735-2739
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number5
DOIs
StatePublished - Feb 27 2001
Externally publishedYes

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Caenorhabditis elegans
Salmonella typhimurium
Cell Death
Gonads
Germ Cells
Neurodegenerative Diseases
Autoimmune Diseases
Intestines
Mammals
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

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